Wednesday, 22 September Ch 11 Endocrine System Seminar: Thursday, 11 am Olin Theater. Diabetes, Stress, & Depression! The Hypothalamus and Pituitary Glands Unique anatomy Long & short loop negative feedback Some examples of endocrine disorders Stress and cortisol

1QQ # 7 Give the definition of “hormone” and explain why, according to this definition, renin isn’t actually a hormone. What’s different about the cells of the zona glomerulosa in the adrenal cortex that allows them to secrete aldosterone but not glucocorticoids? Where does Angiotensin II come from and what does it do? Why do steroid hormones and thyroid hormones remain in the bloodstream much longer than peptide hormones and catecholamine hormones?

Thyroid Gland TH =T3 and T4 S1 Fenestrated Capillary (typical of endocrine glands)

S2 Synthesis, Storage and Secretion of T3 and T4 Roles of TSH (Thyroid Stimulating Hormone) Tropic: directs (controls) Trophic: growth TH increases cell metabolism & heat production (BMR)

Fig. 11.12a S3 Receives input from many regions of brain; many factors Affect its function Homeostatsis center. 11.12a.jpg

6 Fig. 11.12b S4 Neurohypophysis Adenohypophysis 11.12b.jpg 6 Vasopressin (= Antidiuretic hormone) Oxytocin

Typical Blood Flow Portal System Artery – arteriole- capillary –venule- vein –heart Portal System Artery – arteriole- capillary –portal vessel –capillary –venule- vein –heart Hepatic portal system Hypothalamo-hypophyseal portal system Vasculature of nephrons

Release-inhibiting Hormone Tropic hormones control the function Trophic hormones promote survival and growth of targets S 6 A S P Hypothalamo-hypophyseal portal system 11.17.jpg Releasing Hormone Release-inhibiting Hormone

Long-loop negative feedback Tropic hormones control the function Trophic hormones promote survival and growth of targets S 7 Releasing Hormone Release Inhibiting Hormone Short-loop Neg. Feed. Long-loop negative feedback 11.17.jpg