A model of the process of transcellular transport of inorganic phosphate (HPO42- ) across the proximal convoluted tubule of mammalian kidney. The luminal.

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A model of the process of transcellular transport of inorganic phosphate (HPO42- ) across the proximal convoluted tubule of mammalian kidney. The luminal or brush-border membrane is depicted on the left and the basolateral membrane on the right. Both the type I (NPT1) and type II (NPT2A/c) Na+-phosphate cotransporters operate in the luminal membrane. A Na+-phosphate stoichiometry of 3:1 for the type II transporter has been documented. The HPO4 2- that enters the cell across the luminal surface mixes with the metabolic pool of phosphate in the cell and eventually is transported out of the cell across the basolateral membrane via passive diffusion down an electrochemical gradient or via an anion-exchange mechanism. There is also evidence for a Na+-phosphate cotransporter on the basolateral membrane that is distinct from NPT1 and NPT2A/c. Not shown is the basolateral membrane Na+,K+-ATPase that transports Na+ (which enters the cell on its luminal side) out of the cell, thereby maintaining the Na+ gradient driving force for luminal phosphate entry. Source: Mendelian Hypophosphatemias, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch197fg2.png&sec=62654946&BookID=971&ChapterSecID=62654910&imagename= Accessed: January 02, 2018 Copyright © 2018 McGraw-Hill Education. All rights reserved