Why do some survive Ebola?

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Presentation transcript:

Why do some survive Ebola? By A. CRIQUI R. NEMOZ Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola virus - CRIQUI NEMOZ - December 4 2003 PRESENTATION - I Etiology Filoviridae virus (RNA-) Four subtypes Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola infected patient PRESENTATION - II Etiology Symptoms Fever Diarrhoea Vomiting Haemorrhage Ebola infected patient www.virus-ebola.com October 22, 2002 Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola virus - CRIQUI NEMOZ - December 4 2003 PRESENTATION - III Etiology Symptoms Epidemiology Endemic zone Death rate Transmission Expression of the disease www.adam.com October 22, 2002 Ebola is still limited to parts of Africa Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola virus - CRIQUI NEMOZ - December 4 2003 PRESENTATION - IV Etiology Symptoms Epidemiology Treatment Not found yet Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola virus - CRIQUI NEMOZ - December 4 2003 VIRUS TARGETS NE LC sGP Virus EC GP Replication Macro Mono Ebola virus - CRIQUI NEMOZ - December 4 2003

HUMORAL RESPONSE No IgG Few IgM IN SURVIVORS IN FATALITIES EM Leroy - The lancet – Vol 355 – June 24, 2000 DEFECTIVE HUMORAL RESPONSE Ebola virus - CRIQUI NEMOZ - December 4 2003

Baize – Nature medicine Circulating antigen load  No effect of antigen load on IgG production Baize – Nature medicine Vol 5 #4 – April 1999 Circulating antigen load Ebola virus - CRIQUI NEMOZ - December 4 2003

Ebola virus - CRIQUI NEMOZ - December 4 2003 CELLULAR RESPONSE IN SURVIVORS IN FATALITIES Too early Too excessive Acute phase : No T cells activated Clinical recovery : Cytotoxic cells activated T cells death Ebola virus - CRIQUI NEMOZ - December 4 2003

APOPTOSIS Bcl-2 Apoptosis signal PBMC BAIZE – Apoptosis vol 5 #1 - 2000 Bcl-2 41/7 NMP (U/ml) PBMC 41/7 NMP is the evidence of apoptosis Ebola virus - CRIQUI NEMOZ - December 4 2003

Different expressions of the disease CONCLUSION Different immune responses Prevention of transmission Perspectives Different expressions of the disease Ebola virus - CRIQUI NEMOZ - December 4 2003