VACS Polypharmacy Workgroup Amy Justice, MD, PhD Co-Director E. Jennifer Edelman, MD Co-Director Members: K Akgun, W Becker, D Fiellin, M Freiberg, CL Gibert, K Gordon, V Lo Re, J Naples, M Skanderson, M Sung, J Tate, S Viswanathan, D Weisberg, M Wolff, J Womack, C Wyatt, New Members: K Niehoff, A Tseng, and S Khoo

VACS Polypharmacy Workgroup 1: Althoff KN et al. HIV and ageing: improving quantity and quality of life. Curr Opin HIV AIDS. 2016 Sep;11(5):527-536. 2: Weisberg DF et al. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. J Acquir Immune Defic Syndr. 2015 Jun1;69(2):223-33. 3. Justice AC et al. Should everyone ageing with HIV take a statin? Lancet HIV. 2(2)E36-37 Feb 2015 4: Edelman EJ et al. The next therapeutic challenge in HIV: polypharmacy. Drugs Aging. 2013 Aug;30(8):613-28. Cited: 35 times 5: Greene M et al. Management of human immunodeficiency virus infection in advanced age. JAMA. 2013 Apr 3;309(13):1397-405 Cited: 45 times 6: High KP et al. HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. J Acquir Immune Defic Syndr. 2012 Jul 1;60 Suppl 1:S1-18. Cited:129 times

Drug Safety Work in VACS 1: Edelman EJ et al.; VACS Project Team. Acetaminophen receipt among HIV- infected patients with advanced hepatic fibrosis. Pharmacoepidemiol Drug Saf. 2013 Dec;22(12):1352-6. 2: Edelman EJ et al.; Vacs Project Team. Patient-reported symptoms on the antiretroviral regimen efavirenz/emtricitabine/ tenofovir. AIDS Patient Care STDS. 2012 Jun;26(6):312-9. 3: Tetrault JM et al.; Veterans Aging Cohort Study Team. Hepatic safety and antiretroviral effectiveness in HIV-infected patients receiving naltrexone. Alcohol Clin Exp Res. 2012 Feb;36(2):318-24. 4: Justice AC et al; Veterans Aging Cohort Study Project Team. Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage? Clin Infect Dis. 2008 Nov 1;47(9):1226-30.