Figure 3. Biodistribution of Nickel was measured by using ICP-OES technique in (a) liver, (b) kidneys, (c) brain, (d) spleen, (e) heart, (f) blood, (g)

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Figure 3. Biodistribution of Nickel was measured by using ICP-OES technique in (a) liver, (b) kidneys, (c) brain, (d) spleen, (e) heart, (f) blood, (g) urine and (h) feaces. The rats were orally administered with three different doses (125, 250 and 500 mg/kg body weight) of NiO NPs. The results were significantly different from control at *P < 0.05, <sup>**</sup>P < 0.01 and <sup>***</sup>P < 0.001 (n = 5). From: Genotoxicity study of nickel oxide nanoparticles in female Wistar rats after acute oral exposure Mutagenesis. 2017;32(4):417-427. doi:10.1093/mutage/gex007 Mutagenesis | © The Author 2017. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 1