Transient Receptor Potential (TRP) Channels

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Presentation transcript:

Transient Receptor Potential (TRP) Channels First discovered in Drosophila: Drosophila eye에서 photo-transduction Light → rhodopsin → GPCR → G transducin → PLC activation → Ca2+ → currents → channel activation

Transient receptor potential channel in Drosophila Eye Craig Montel & Gerald M Rubin. Molecular Characterization of the Drosophila trp locus: A Putative Integral Membrane Protein Required for Phototransduction. Neuron, 1989

Discovery of VR1 (capsaicin receptor) in mouse DRG neurons Michael J. Caterina et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997

TRPV1 is activated by heat! Tominaga, Neuron 1998

Classification of TRP channels Nonselective Cation channels

TRP channels are activated by natural ingredients

TRP Channels: Molecular Sensors Capsaicin 감각 신경 척수 유해자극 (열, 압력, 캡사이신) 대뇌 통증 전달 경로 이온채널 heat

TRPV4-associated skeletal dysplasias