Fig. 2. ERK phosphorylation is elevated in dystrophic muscle

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Fig. 2. ERK phosphorylation is elevated in dystrophic muscle Fig. 2. ERK phosphorylation is elevated in dystrophic muscle. A: phosphorylated and total ERK1/2 were measured in homogenates of resting EDL muscles dissected from normal (C57), γ-sarcoglycan (γ-SG)-null (gsg−/−), and dystrophin-null (mdx) mice and normalized to total protein. B: both gsg−/− and mdx muscles exhibited significantly increased P-ERK1 compared with C57 muscles (*P < 0.05), and gsg−/− muscles also had significantly elevated P-ERK2 (*P < 0.05). C: there was no significant difference in total ERK content among any of the mouse strains. Published in: Elisabeth R. Barton; American Journal of Physiology-Cell Physiology 2006, 290, C411-C419. Copyright © 2006