DISORDERS DUE TO DEFECTS IN COLLAGEN

Defects in Type I collagen cause: OSTEOGENESIS IMPERFECTA Blue sclera In support of chapter 8, pg. 6 Left panel from Langlais - Color Atlas of Common Oral Diseases. See the DVD. Right panel from Wikipedia.

Defects in Type I collagen cause: DENTINOGENESIS IMPERFECTA Abraded teeth in Dentinogenesis Imperfecta Opalescent and cracked teeth In support of chapter 8, pg. 6 Left panel from Langlais - Color Atlas of Common Oral Diseases. See the DVD. Right panel from Wikipedia. Type I: associated with OI. Will probably need full crown coverage.

An example of a mutation underlying Osteogenesis Imperfecta 988 Pro Gly Pro Arg Gly Arg Thr Gly Asp Ala CCG GGT CCT CGC GGT CGC ACT GGT GAT GCT Pro Cys Pro Arg Gly Arg Thr Gly Asp Ala CCT TGT CCT CGC GGT CGC ACT GGT GAT GCT In support of Chapter 8, pg. 6.

Ehlers-Danlos Syndrome Hyperplasticity of the skin In support of chapter 8, pg. 6 From Mosby's Medical, Nursing and Allied Health Dictionary. See DVD.

Perifollicular abnormalities. Gingival abnormalities Scurvy In support of chapter 8, pg. 8. Figs. from Hisrschmann, J.V., and Raugi, G. J. Adult scurvy. J. Am. Acad. Dermatol. 41:895-906. (1999) Perifollicular abnormalities. Gingival abnormalities

Genetic defects in elastin underlie Williams Syndrome Facial features associated with Williams Syndrome Dental features include small widely spaced teeth and malocclusion. In support of chapter 8, pg. 10. From Morris CA, and Mervis CB. Williams Syndrome and related disorders. Ann. Rev. Genomics Hum. Genet. 1:461-484. (2000).

Abraham Lincoln is thought to have had Marfan’s syndrome. Image from Wikipedia.

Aortic Aneurysm CT reconstruction of an aortic aneurysm. The Figure is from Wikipedia.