FIGURE 1. Relative risk (RR) of clubfoot associated with having one or two copies versus no copies of the methylenetetrahydrofolate reductase gene (MTHFR)

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FIGURE 1. Relative risk (RR) of clubfoot associated with having one or two copies versus no copies of the methylenetetrahydrofolate reductase gene (MTHFR) variant T allele, within strata of maternal folic acid use during the periconceptional period of the index pregnancy, United Kingdom, children born in 1963–2002. A, mother's alleles; B, child's alleles; vertical lines, 95% confidence intervals for the risk estimates. From: The C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene (MTHFR), Maternal Use of Folic Acid Supplements, and Risk of Isolated Clubfoot: A Case-Parent-Triad Analysis Am J Epidemiol. 2006;164(9):852-861. doi:10.1093/aje/kwj285 Am J Epidemiol | American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

FIGURE 2. Relative risk (RR) of clubfoot associated with having one or two copies versus no copies of the methylenetetrahydrofolate reductase gene (MTHFR) variant T allele, within strata of maternal alcohol consumption during the index pregnancy, United Kingdom, children born in 1963–2002. A, mother's alleles; B, child's alleles; vertical lines, 95% confidence intervals for the risk estimates. From: The C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene (MTHFR), Maternal Use of Folic Acid Supplements, and Risk of Isolated Clubfoot: A Case-Parent-Triad Analysis Am J Epidemiol. 2006;164(9):852-861. doi:10.1093/aje/kwj285 Am J Epidemiol | American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

FIGURE 3. Relative risk (RR) of clubfoot associated with having one or two copies versus no copies of the methylenetetrahydrofolate reductase gene (MTHFR) variant T allele, within strata of family history of clubfoot, United Kingdom, children born in 1963–2002. A, mother's alleles; B, child's alleles; vertical lines, 95% confidence intervals for the risk estimates. From: The C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene (MTHFR), Maternal Use of Folic Acid Supplements, and Risk of Isolated Clubfoot: A Case-Parent-Triad Analysis Am J Epidemiol. 2006;164(9):852-861. doi:10.1093/aje/kwj285 Am J Epidemiol | American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.