Iron, inflammation and atherosclerosis risk in men vs

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Iron, inflammation and atherosclerosis risk in men vs Iron, inflammation and atherosclerosis risk in men vs. perimenopausal women Subha V. Raman, Travis P. Sharkey-Toppen, Tam Tran, Jim X. Liu, Beth McCarthy, Xin He, Suzanne Smart, Martha Gulati, Randell Wexler, Orlando P. Simonetti, Rebecca D. Jackson Atherosclerosis Volume 241, Issue 1, Pages 249-254 (July 2015) DOI: 10.1016/j.atherosclerosis.2015.03.032 Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Carotid Artery Wall Volume Measurement 3D T1W-TSE magnetic resonance images of the right internal (A-1) and common (A-2) carotid artery are shown. Orthogonal sections through the arterial wall are generated (B) for wall volume measurement. Manually delineated inner and outer vessel wall contours are shown (C) for the same common carotid artery. Atherosclerosis 2015 241, 249-254DOI: (10.1016/j.atherosclerosis.2015.03.032) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Interobserver Agreement in Carotid Artery Wall T2* and Wall Volume Bland–Altman plots of arterial wall T2* (top) and wall volume (bottom) measurements show good agreement between 2 reviewers. The Bland–Altman mean interobserver difference in T2* was 0.1 ms (95% confidence interval [CI], −3.7–3.9 ms), and this difference was 8.2 mL for wall volume (95% confidence interval [CI], −37.4–53.9). Atherosclerosis 2015 241, 249-254DOI: (10.1016/j.atherosclerosis.2015.03.032) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Arterial Wall MRI vs. Systemic Inflammatory Biomarkers in Perimenopausal Women vs. Men The magnetic resonance imaging biomarker T2* measured in the carotid artery wall of women entering perimenopause shows a significant correlation with serum levels of hsCRP (r = −0.3139, P = 0.0014). This relationship is weaker as women transition through perimenopause (r = −0.1718, P = 0.0859) and is insignificant in men of similar age and risk factor profile (r = −0.0310, P = 0.8362). Atherosclerosis 2015 241, 249-254DOI: (10.1016/j.atherosclerosis.2015.03.032) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Carotid Artery Wall T2* vs. Serum Ferritin Levels in Perimenopausal Women vs. Men. At baseline, T2* in the carotid arterial wall of women entering perimenopause significantly decreases with increasing levels of serum ferritin (r = −0.3163, P = 0.0013). This correlation was weaker over the 24-month follow-up period as women transitioned through menopause (r = −0.0730, P = 0.4684) and was insignificant in men of similar age and risk factor profile (r = 0.0862, P = 0.5644). Atherosclerosis 2015 241, 249-254DOI: (10.1016/j.atherosclerosis.2015.03.032) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Atherosclerosis 2015 241, 249-254DOI: (10. 1016/j. atherosclerosis Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions