Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia Sosa.

Slides:



Advertisements
Similar presentations
LW-AFC Effects on N -glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer#cod#x02019;s Disease Wang Jianhui 1, 2 ;Cheng.
Advertisements

LW-AFC Effects on N -glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer#cod#x02019;s Disease Jianhui Wang 1, 2,
Volume 76, Issue 7, Pages (October 2009)
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway Zhang Meng 1 ;Deng Yong-Ning 1 ;Zhang.
The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice Zhao Guangxian 1 ;W. Cheng Xian 1, 7, 8 ;Piao Limei 1, 2 ;Hu Lina.
Yang Changjun;M. DeMars Kelly;Candelario-Jalil#cod#x0002A; Eduardo;
Raju Murugesan 1 ;Santhoshkumar Puttur 1 ;Krishna Sharma K. 1, 2 ;
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway Zhang Meng 1 ;Deng Yong-Ning 1 ;Zhang.
Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer#cod#x00027;s Disease Involves Nrf2/HO-1 Pathway Morroni Fabiana 1.
Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP Liu Xiangrong 1, 2, 3 ;Wen Shaohong 1, 2,
Guangxian Zhao 1, # ;Xian W
Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke Zhang Jun 1 ;Liu Kaiyin 2 ;Elmadhoun.
The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice Zhao Guangxian 1 ;W. Cheng Xian 1, 7, 8 ;Piao Limei 1, 2 ;Hu Lina.
Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer#cod#x02019;s.
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice Liu Huaqin 1, 2 ;Yu Zhui 1, 3 ;Li Ying 1, 4 ;Xu Bin 1, 5 ;Yan Baihui.
Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP Liu Xiangrong 1, 2, 3 ;Wen Shaohong 1, 2,
Peng Fangyu 1, 2 ;Xie Fang 1 ;Muzik Otto 3, 4 ;
Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1 Li Yun;Mei Zhu;Liu Shuiqiao;Wang Tong;Li Hui;Li Xiao-Xiao;Han.
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Cai Mengfei 1 ;Zhang Wenting.
Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice Urzua Ulises 1, 4, 5 ;Chacon Carlos 1 ;Lizama.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Mengfei Cai 1 ;Wenting.
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia Sosa.
Figure 2. Macrophages in dystrophic muscle in vivo and in vitro express Klotho. (A) A cross-section of 4-week-old mdx muscle labeled with antibodies to.
Volume 18, Issue 3, Pages (September 2013)
Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease  Sandhya S. Thomas, Yanjun Dong,
Volume 58, Issue 5, Pages (November 2000)
Volume 69, Issue 8, Pages (April 2006)
Michael Eikmans, Hans J. Baelde, Emile De Heer, Jan A. Bruijn 
Volume 16, Issue 10, Pages (September 2016)
I LC3 II a-Tubulin Figure S1 Ctrl Myoblasts 0h shMLP Myoblasts 0 h
Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing σ in the Epidermis  Francesca Cianfarani, Silvia.
Volume 69, Issue 12, Pages (June 2006)
Volume 128, Issue 5, Pages (May 2005)
NCOA4 Deficiency Impairs Systemic Iron Homeostasis
Volume 58, Issue 2, Pages (August 2000)
Molecular Therapy - Nucleic Acids
Volume 62, Issue 3, Pages (September 2002)
SS-31 reduces inflammation after acute renal ischemia.
PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice
Antagonism of Myostatin Enhances Muscle Regeneration During Sarcopenia
Volume 74, Issue 2, Pages (July 2008)
Regulation of renal proximal tubular epithelial cell hyaluronan generation: Implications for diabetic nephropathy  Stuart Jones, Suzanne Jones, Aled Owain.
Growth hormone promotes glomerular lipid accumulation in bGH mice
The Rho-kinase pathway regulates angiotensin II-induced renal damage
Volume 60, Issue 3, Pages (September 2001)
Volume 24, Issue 2, Pages (February 2016)
Volume 72, Issue 4, Pages (August 2007)
Volume 76, Issue 7, Pages (October 2009)
Volume 96, Issue 3, Pages (February 1999)
Volume 48, Issue 5, Pages (December 2012)
Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells  Feng.
Volume 119, Issue 2, Pages (August 2000)
Overexpression of Fetuin-A Counteracts Ectopic Mineralization in a Mouse Model of Pseudoxanthoma Elasticum (Abcc6−/−)  Qiujie Jiang, Florian Dibra, Michael.
Volume 21, Issue 6, Pages (June 2012)
Volume 84, Issue 4, Pages (October 2013)
Aishwarya Sathyanarayan, Mara T. Mashek, Douglas G. Mashek 
Volume 62, Issue 2, Pages (August 2002)
Volume 23, Issue 8, Pages (August 2015)
NCOA4 Deficiency Impairs Systemic Iron Homeostasis
The Relaxin Gene Knockout Mouse: A Model of Progressive Scleroderma
Quan Jin, Chunping Qiao, Jianbin Li, Juan Li, Xiao Xiao 
Volume 59, Issue 1, Pages (January 2001)
Presentation transcript:

Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia Sosa Patricia 1 ;Alcalde-Estevez Elena 1, 2 ;Plaza Patricia 1 ;Troyano Nuria 1 ;Alonso Cristina 3 ;Mart#cod#x000ED;nez-Arias Laura 4 ;Evelem de Melo Aroeira Andresa 1 ;Rodriguez-Puyol Diego 2, 5, 6 ;Olmos Gemma 1, 6 ;L#cod#x000F3;pez-Ongil Susana 2, 6 ;P. Ru#cod#x000ED;z-Torres Mar#cod#x000ED;a 1, 6 ; 1 System Biology Department, Alcala University, Alcal#cod#x000E1; de Henares, Madrid, Spain. ; 2 Research Unit, Biomedical Research Foundation from Pr#cod#x000ED;ncipe de Asturias University Hospital, Alcal#cod#x000E1; de Henares, Madrid, Spain. ; 3 Geriatric and Frailty Section, Getafe University Hospital, Getafe, Madrid, Spain. ; 4 Bone and Mineral Research Unit, Hospital Universitario Central de Asturias. Instituto de Investigaci#cod#x000F3;n Sanitaria del Principado de Asturias. Red de Investigaci#cod#x000F3;n Renal (REDinREN#cod#x0005D; del ISCIII. Oviedo. Spain ; 5 Nephrology Section, Biomedical Research Foundation from Principe de Asturias University Hospital, Alcal#cod#x000E1; de Henares, Madrid, Spain ; 6 Instituto Reina Sof#cod#x000ED;a de Investigaci#cod#x000F3;n Nefrol#cod#x000F3;gica, IRSIN, Madrid, Spain. ; Figure 7. Aged mice present elevated serum phosphate linked to higher expression of ILK and senescence genes and loss of muscle strength. Twenty-four-month-old mice Old were compared with five-month-old ones Young. A Serum phosphate concentration was assessed by a colorimetric method. Graph represents the mean #cod#x000B1; SEM from values obtained from 10 animals per group. #cod#x0002A; p#cod#x0003C; 0.05 vs young. B-D p53 B, ILK C and p62 D expression was evaluated by western blot in protein extracts isolated from vastus from old and young mice. A representative blot is shown in each case. Bar graphs represent the densitometric analysis of the bands. The results are expressed as a percentage of young mice and are the mean #cod#x000B1; SEM from ten animals per group. #cod#x0002A; p#cod#x0003C; 0.05 vs young. E Forelimb grip strength test was performed in young and old mice. Results are mean #cod#x000B1; SEM from ten animals per group. #cod#x0002A; p#cod#x0003C; 0.05 vs young. null,null,0(0),null-null. Doi:10.14336/AD.2017.1214

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.