Volume 148, Issue 5, Pages (November 2015)

Slides:

Advertisements

Similar presentations

Volume 32, Issue 1, Pages (July 1957)

Advertisements

Tell-tale Telangiectasias

Volume 104, Issue 2, Pages (August 1993)

Colloquium on Therapy of Right Heart Failure

Aortic Root Replacement in a Patient With Vancomycin-Resistant Enterococcus faecium Endocarditis and Leukemia Igor E. Konstantinov, MD, Kenton J. Zehr,

When to Be Rash About a Fever and Headache

Volume 102, Issue 3, Pages (September 1992)

Epidemiology and Treatment of Lung Cancer in Seattle

Volume 112, Issue 1, Pages (July 1997)

Hyperbaric Oxygenation in Cardiac and Pulmonary Disease

Volume 125, Issue 4, Pages (April 2004)

Air Pollution and Chest Disease

Rheumatic Heart Disease in East Pakistan

Navin K. Jain, MD, Thiam H. Lie, MD, FCCP CHEST

Volume 138, Issue 5, Pages (November 2010)

Volume 123, Issue 2, Pages (February 2003)

Clinical and Personality Profiles and Survival in Patients With COPD

Effects of Prostaglandin E1 on Oxygen Delivery and Consumption in Patients with the Adult Respiratory Distress Syndrome Henry J. Silverman, M.D., F.C.C.P.

Upper Airways Obstruction with Bilateral Vocal Cord Paralysis

Volume 113, Issue 4, Pages (April 1998)

Frank W. Ewald, MD, FCCP, Albert H. Scherff, MD CHEST

Volume 142, Issue 1, Pages (July 2012)

Volume 143, Issue 1, Pages (January 2013)

Volume 151, Issue 3, Pages (March 2017)

Breath Analysis in Pulmonary Arterial Hypertension

Volume 152, Issue 5, Pages (November 2017)

COUNTERPOINT: Is the Apnea-Hypopnea Index the Best Way to Quantify the Severity of Sleep-Disordered Breathing? No Naresh M. Punjabi, MD, PhD, FCCP CHEST

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Flow Volume Loop CHEST Volume 97, Issue 5, Pages (May 1990)

Arterial Line or Cuff BP?

Volume 141, Issue 5, Pages (May 2012)

Spread the Word About CHEST in 2018

Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite–sensitive patients with asthma Kittipong Maneechotesuwan, MD,

Airway Wall Expression of OX40/OX40L and Interleukin-4 in Asthma

Airway Stenting for Patients With Benign Airway Disease and the Food and Drug Administration Advisory Lund Mark E. , MD, FCCP, Force Seth , MD, FCCP

Volume 141, Issue 5, Pages (May 2012)

Point: Should Medicare Allow Respiratory Therapists to Independently Practice and Bill for Educational Activities Related to COPD? Yes Thomas M. Fuhrman,

Volume 147, Issue 1, Pages (January 2015)

Sundeep Salvi, MD, DNB, PhD, FCCP, Peter J. Barnes, DM, FCCP CHEST

Counterpoint: Should All ICU Patients Receive Continuous Sedation? No

Volume 145, Issue 2, Pages (February 2014)

Volume 104, Issue 1, Pages 1-2 (July 1993)

New CHEST Associate Editors Named

Imaging for the Management of Community-Acquired Pneumonia

Point: Should We Abandon FEV1/FVC <0

Spread the Word About CHEST in 2015

Possible Role of Statins in COPD-Related Pulmonary Hypertension

Volume 97, Issue 1, Pages (January 1990)

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

Evolution in Reimbursement for Sleep Studies and Sleep Centers

Volume 92, Issue 1, Pages (July 1987)

Bedside Calibration Of Pulmonary Artery Catheters

Invasive Pulmonary Aspergillosis

Pulmonary Manifestations in a Case of Multiple Myeloma

Volume 42, Issue 2, Pages (August 1962)

Calcification of the Coronary Artery

Volume 150, Issue 4, Pages (October 2016)

John M. Yackee, M.D., Reed M. Shnider, M.D., Alan G. Wasserman, M.D.

Volume 72, Issue 5, Pages (November 1977)

Volume 138, Issue 5, Pages (November 2010)

Counterpoint: Should Medicare Allow Respiratory Therapists to Independently Practice and Bill for Educational Activities Related to COPD? No Katherine.

Thoracic Surgery Survey on Lung Cancer Management

Systemic Inflammation, COPD, and Pulmonary Hypertension

Use of Endobronchial Ultrasound for Bedside Diagnosis of Acute Pulmonary Embolism in a Critically Ill Patient Colleen L. Channick, MD, FCCP, Richard.

Volume 138, Issue 5, Pages (November 2010)

Frederick E. Hargreave, MBChB, MD, Parameswaran Nair, MD, PhD CHEST

Arterial Line or Cuff BP?

New Members of the Editorial Board

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids Kittipong Maneechotesuwan, MD, PhD, Sirinya.

Presentation transcript:

Volume 148, Issue 5, Pages 1164-1176 (November 2015) Simvastatin Suppresses Airway IL-17 and Upregulates IL-10 in Patients With Stable COPD Kittipong Maneechotesuwan, MD, PhD, Adisak Wongkajornsilp, MD, PhD, Ian M. Adcock, PhD, Peter J. Barnes, DM, Master FCCP CHEST Volume 148, Issue 5, Pages 1164-1176 (November 2015) DOI: 10.1378/chest.14-3138 Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Flow of subjects through the study. CHEST 2015 148, 1164-1176DOI: (10.1378/chest.14-3138) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 2 A, B, The lowering of sputum IL-17A (A) and IL-22 (B) concentrations in response to simvastatin treatment to a greater extent than placebo. Data are expressed as mean (SD). Δ = change in. CHEST 2015 148, 1164-1176DOI: (10.1378/chest.14-3138) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 3 A, The elevation of sputum IL-10 concentrations was greater in response to simvastatin treatment than placebo. B, The same pattern was seen in IDO messenger RNA concentration. C, IDO activity also was elevated in response to simvastatin treatment to a greater extent than placebo. The data are expressed as mean (SD). IDO = indoleamine 2,3-dioxygenase; Kyn = kynurenine; Tryp = tryptophan. See Figure 2 legend for expansion of other abbreviation. CHEST 2015 148, 1164-1176DOI: (10.1378/chest.14-3138) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 4 A, Sputum IL-6 concentration was lower in response to simvastatin treatment to a greater extent than placebo. B, The same pattern was seen in CXCL8 concentrations. The data are expressed as mean (SD). See Figure 2 legend for expansion of other abbreviation. CHEST 2015 148, 1164-1176DOI: (10.1378/chest.14-3138) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 5 A, Absolute macrophage counts were lower in response to simvastatin treatment to a greater extent than placebo. B, A similar pattern was seen in the proportion of macrophages (% of total cells). The data are expressed as mean (SD). CHEST 2015 148, 1164-1176DOI: (10.1378/chest.14-3138) Copyright © 2015 The American College of Chest Physicians Terms and Conditions