Functions of microRNA-33a/b and microRNA therapeutics

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Functions of microRNA-33a/b and microRNA therapeutics Koh Ono, MD, PhD, FJCC Journal of Cardiology Volume 67, Issue 1, Pages 28-33 (January 2016) DOI: 10.1016/j.jjcc.2015.10.017 Copyright © 2015 Japanese College of Cardiology Terms and Conditions

Fig. 1 Mice have a single copy of microRNA (miR)-33, but humans have two copies (miR-33a and miR-33b). Journal of Cardiology 2016 67, 28-33DOI: (10.1016/j.jjcc.2015.10.017) Copyright © 2015 Japanese College of Cardiology Terms and Conditions

Fig. 2 Lipid profiles of wild-type (WT), microRNA (miR)-33a-deficient mice (knockout, KO), and miR-33b knock-in (KI) mice (cited and modified from Refs. [9,12]). (A) Representative high-performance liquid chromatography (HPLC) analysis of serum cholesterol from male wild-type and miR-33a-deficient mice. (B) Representative HPLC analysis of serum cholesterol from male wild-type and miR-33b KI+/+ mice. Journal of Cardiology 2016 67, 28-33DOI: (10.1016/j.jjcc.2015.10.017) Copyright © 2015 Japanese College of Cardiology Terms and Conditions

Fig. 3 microRNA (miR)-33a-deficiency reduced atherosclerosis (cited and modified from Ref. [10]). (A) Representative microscopic images of cross-sections of the proximal aorta in miR-33+/+Apoe−/− and miR-33−/−Apoe−/− male and female mice. Scale bars, 1mm. (B) Quantification of the atherosclerotic plaque area in cross-sections of the proximal aorta in male and female mice. Values are the means±S.E. (n=10–11 each, *p<0.05). Journal of Cardiology 2016 67, 28-33DOI: (10.1016/j.jjcc.2015.10.017) Copyright © 2015 Japanese College of Cardiology Terms and Conditions

Fig. 4 microRNA (miRNA) manipulation strategies. Modification of miRNAs can be achieved by several strategies. Red lines indicate the methods to increase target gene expression and blue lines indicate approaches to reduce them. (A) AntagomiRs and antimiRs for miRNA inhibition. (B) BlockmiRs for specific target inhibition. (C) miRNA sponges for miRNA inhibition. (D) miRNA mimics for miRNA replacement. Journal of Cardiology 2016 67, 28-33DOI: (10.1016/j.jjcc.2015.10.017) Copyright © 2015 Japanese College of Cardiology Terms and Conditions