Supplementary Figure 1. Deficits in cognitive function persist up to 11 wks post-injury in moderate-level CCI TBI mice. Sham-injured and CCI TBI mice.

Slides:

Advertisements

Similar presentations

Research Methods in Psychology Spring 2012, PSYC I. A brief description of the Morris water maze task used to measure spatial navigation in rodents.

Advertisements

Summary of: Distinct Components of Spatial Learning Revealed by Prior Training and NMDA Receptor Blockade Presentation By: Carmine Ciccone Spencer Jenkyns.

Deficits in Spatial Cognition After TBI Revealed By Virtual Morris Water Maze R.W. Skelton & S.P. Ross, Psychology, University of Victoria, Victoria, BC,

Examination of the State Dependent Properties of WIN on Spatial Learning and Memory in Rats in the Sand Maze Ashley R. Smith and Gretchen Hanson.

A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory E. R. Escobedo 1, K. Magnusson 2,3 — 1 BioResource.

ANOVA. Independent ANOVA Scores vary – why? Total variability can be divided up into 2 parts 1) Between treatments 2) Within treatments.

Review of Results From data analysis to presentation.

Spatial Learning and Memory in the Sand Maze: Does WIN-2 Produce State Dependent Retention in Rats? Ashley R. Smith and Gretchen Hanson Gotthard Randolph-Macon.

Effects of age on navigation strategy 期刊： Neurobiology of Aging 作者： M. Kirk Rodgers, Joseph A. Sindone III, Scott D. Moffat 學生：林怡儒 M

TLR4 signal ablation attenuated neurological deficits by regulating microglial M1/M2 phenotype after traumatic brain injury in mice Xiaolong Yao, Shengwen.

Parameter WT Rnd3+/- n 7 Body weight (g) 25.59± ±2.11

From: Propofol Limits Microglial Activation after Experimental Brain Trauma through Inhibition of Nicotinamide Adenine Dinucleotide Phosphate Oxidase Anesthes.

Faezeh Tashakori Sabzevar

Fus1 KO female mice have olfactory and spatial memory impairments and

BEHAVIOR AND MEMORY EVALUATION OF RATS TREATED WITH SIMVASTATIN IN THE SCOPOLAMINE ANIMAL MODEL TONIN, F. S.; BARBIERO, J. K. Departamento de Farmacologia,

From: Nerve Injury-related Autoimmunity Activation Leads to Chronic Inflammation and Chronic Neuropathic Pain Anesthes. 2013;118(2): doi: /ALN.0b013e31827d4b82.

Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment Makoto Kondo, Yosuke Takei, Nobutaka.

Examination of the State Dependent Properties of WIN on Spatial Learning and Memory in Rats in the Sand Maze Ashley R. Smith and Gretchen Hanson.

Body weight at harvest (g) Left kidney:body weight ratio (g/kg)

PERK activator reduces behavioral deficits and neurodegeneration in vivo PERK activator reduces behavioral deficits and neurodegeneration in vivo A–CYoung.

Repeated administration of RGFP-966 improves short-term recognition and spatial memory in 3xTg-AD mice. Repeated administration of RGFP-966 improves short-term.

Xenon: no stranger to anaesthesia

Cognitive deficits in APPPS1‐21 mice.

Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model F. Mardini, J.X. Tang, J.C. Li, M.J. Arroliga,

Randolph-Macon Woman’s College

Volume 21, Issue 2, Pages (August 1998)

Volume 32, Issue 5, Pages (December 2001)

Volume 13, Issue 12, Pages (December 2015)

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

The relationship between dorsal horn neurotransmitter content and allodynia in neuropathic rats treated with high-frequency transcutaneous electric nerve.

Volume 8, Issue 1, Pages (January 2017)

Acetylcholine-secreting cells improve age-induced memory deficits

Riboflavin may ameliorate neurological motor disability but not spatial learning and memory impairments in murine model of multiple sclerosis Mahshid.

G. Xu, H. Lu, Y. Dong, D. Shapoval, S. G. Soriano, X. Liu, Y. Zhang, Z

Volume 15, Issue 9, Pages (May 2016)

Matthew B. Potts, Daniel A. Lim Cell Stem Cell

Volume 4, Issue 3, Pages (August 2013)

Volume 11, Issue 2, Pages (April 2015)

Volume 32, Issue 5, Pages (December 2001)

(A) (B) Supplementary figure S1

Cognition and Immunity

Results from the Morris water task.

Volume 20, Issue 4, Pages (September 2013)

Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity R.D. Sanders, D. Ma, P. Brooks, M.

Volume 42, Issue 1, Pages (April 2004)

Whole body exposure with GSM 900MHz affects spatial memory in mice

Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour F.S. Hasnie,

Morris Water Maze Experiment

Volume 135, Issue 3, Pages (October 2008)

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease Fang Huang, Minghui Wang, Rong Liu, Jian-Zhi Wang, Eric Schadt, Vahram.

Supplementary Figure 5: Effect of S48168 on normalized organ and skeletal muscle weights after 12 weeks of treatment for all the experimental groups from.

Performance of chronic METH-treated rats in the gambling test under the double-reward condition. Performance of chronic METH-treated rats in the gambling.

Fig. 2 Social transfer of alcohol withdrawal–induced mechanical sensitivity to nearby water-drinking controls. Social transfer of alcohol withdrawal–induced.

Biphasic ambulatory activity and reduced avoidance in Id2−/− mice.

A: Total number of neurons in L5 dorsal root ganglia of long-term diabetic, recovered, and nondiabetic mice. A: Total number of neurons in L5 dorsal root.

Volume 38, Issue 2, Pages (April 2003)

Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.

Male FBN-ARO-KO mice exhibit cognitive defects but normal locomotor activity and anxiety levels. Male FBN-ARO-KO mice exhibit cognitive defects but normal.

NF-κB is central to the relationship between UA and cognitive dysfunction. NF-κB is central to the relationship between UA and cognitive dysfunction. The.

Volume 9, Issue 3, Pages (September 2017)

Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

Supplementary figure 1 A B Water (Control) Pre-alcohol Post-alcohol

NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone.

Cytokine expression in the ileum and colon.

Fig. 3. Effects of RP on SPS-CF stress-induced memory impairment of spatial memory. (A) Latency to find hidden platform in Morris water maze during 5 daily.

Fig. 7 FAE-20 increases hippocampal excitability and leads to more stable contextual fear memory in mice. FAE-20 increases hippocampal excitability and.

Yonghong Chen, Shujuan Zheng, Luis Tecedor, Beverly L. Davidson

Volume 10, Issue 2, Pages (January 2000)

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

γδ T cells producing IL-17 are required for short-term memory.

Presentation transcript:

Supplementary Figure 1. Deficits in cognitive function persist up to 11 wks post-injury in moderate-level CCI TBI mice. Sham-injured and CCI TBI mice performed the Morris water maze test at 4 wks post-injury and again at 11 wks post-injury to assess long-term deficits in cognitive function. The hidden submerged platform was placed in the SW quadrant for the 4 wk post-injury study and in the NE quadrant in the 11 wk post-injury study. Latency to find the platform was recorded by BIANYmaze video-tracking software over a series of 16 training trials (4 trials per day over 4 consecutive days). Repeated measures one-way ANOVA showed a statistically significant interaction between groups and time after injury at 4 wks post-injury (F(3,72)=6.29, p=0.007), but not at 11 wks post-injury (F(3, 54)=2.75, p=0.0514). Post-hoc analysis revealed a significant difference between sham-injured and CCI TBI groups on days 3 and 4 in the 4 wk post-injury study (p<0.001), and on day 4 in the 11 wk post-injury study (p<0.01). 4 wk study: n = 10 sham-injured, n = 18 CCI TBI; 11 wk study: n = 8 sham-injured, n = 12 CCI TBI.