Plasma Orexin-A Levels and Body Composition in COPD Matsumura Takeshi , MD, Nakayama Mika , MD, Satoh Hiroaki , MD, Naito Asuka , MD, Kamahara Kazuyuki , MD, Sekizawa Kiyohisa , MD  CHEST  Volume 123, Issue 4, Pages 1060-1065 (April 2003) DOI: 10.1378/chest.123.4.1060 Copyright © 2003 The American College of Chest Physicians Terms and Conditions

Figure 1 BMI (top left, A), FM (top right, B), FFM (bottom left, C), and plasma orexin-A (bottom right, D) levels in control subjects (open columns), NW group patients (hatched columns), and UW group patients (closed columns). Results are reported as mean ± SE. Significant differences between two columns are indicated by *p < 0.05 and **p < 0.01. CHEST 2003 123, 1060-1065DOI: (10.1378/chest.123.4.1060) Copyright © 2003 The American College of Chest Physicians Terms and Conditions

Figure 2 Relationship between BMI and plasma orexin-A levels (top, A), FM and plasma orexin-A levels (center, B), and FFM and plasma orexin-A levels (bottom, C) in patients with COPD. In patients with COPD, plasma orexin-A levels significantly correlated with BMI (r = 0.49, p = 0.03) [top, A] and FM (r = 0.53, p = 0.03) [center, B] values, whereas a significant relationship was not observed between FFM values and plasma orexin-A levels (r = 0.22, p = 0.35) [bottom, C]. CHEST 2003 123, 1060-1065DOI: (10.1378/chest.123.4.1060) Copyright © 2003 The American College of Chest Physicians Terms and Conditions

Figure 3 Relationship between BMI and FEV1 percentage of predicted (% pred) (top left, A), FM and FEV1 percentage of predicted (top right, B), FFM and FEV1 percentage of predicted (bottom left, C), and plasma orexin-A levels and FEV1 percentage of predicted (bottom right, D) in patients with COPD. Neither BMI (r = 0.39, p = 0.09) [top left, A], FM (r = 0.38, p = 0.10) [top right, B], FFM (r = 0.16, p = 0.48) [bottom left, C], nor plasma orexin-A levels (r = 0.07, p = 0.77) [bottom right, D] were significantly correlated with FEV1 percentage of predicted in patients with COPD. CHEST 2003 123, 1060-1065DOI: (10.1378/chest.123.4.1060) Copyright © 2003 The American College of Chest Physicians Terms and Conditions