Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells  Brita Singers Sørensen, Morten Busk, Nadine Olthof, Ernst-Jan Speel, Michael R. Horsman, Jan Alsner, Jens Overgaard  Radiotherapy and Oncology  Volume 108, Issue 3, Pages 500-505 (September 2013) DOI: 10.1016/j.radonc.2013.06.011 Copyright © 2013 Terms and Conditions

Fig. 1 Gene expression under hypoxia. Relative gene expression of 31 genes under hypoxia, normalized to the gene expression level under normoxia. Data are the mean values of three independent experiments. Error bars represents standard deviation (n=3) (A). Heat map of the 31 genes. Data from three independent experiments are shown. The color bar is showing the fold change relative to the median expression of each gene across all cell lines and conditions. Data are log2 transformed (B). Radiotherapy and Oncology 2013 108, 500-505DOI: (10.1016/j.radonc.2013.06.011) Copyright © 2013 Terms and Conditions

Fig. 2 Radiosensitivity of cell lines. Cell survival curves of all included cell lines under normoxia (A), or the individual cell lines cells after irradiation under either normoxic, hypoxic or hypoxia +1mM Nimorazole conditions (B–F). The linear quadratic model is fitted to the data. OER and SER are calculated at SF10%. The error bars represent the standard deviations (n=6–12). Radiotherapy and Oncology 2013 108, 500-505DOI: (10.1016/j.radonc.2013.06.011) Copyright © 2013 Terms and Conditions