CoolCurve+ Applicator Launch

Introducing the CoolCurve+ Applicator The new CoolCurve+ (“CoolCurve Plus”) applicator is anatomically designed to optimize fit on patients’ bodies. The curved cooling plate allows for better fit and tissue draw, which may yield improved outcomes. Curved cooling plate enables better fit and tissue draw Slim side profile for better usability As the newest addition to our CoolSculpting product line, the CoolCurve+ provides you with increased versatility to treat a multitude of body shapes to attract more patients and grow your practice. IC 1218

CoolCurve+ Optimizes Fit & Tissue Draw On some patients, the CoolCurve (eZ App 6.2) applicator does not provide a tight fit and seal, thus compromising placement and tissue draw. The CoolCurve+ applicator has a curved cooling plate to enable better placement and fit onto the patient’s body. Better tissue draw results. IC 1218

CoolCurve+ Development Research Research conducted in Japan and U.S. 55 typical patients assessed # of Females/ Males 34/ 21 Average Age: 39.9 Average Female BMI: 23.5 Average Male BMI: 25.7 6 different applicator prototypes tested 49 of 55 (89%) demonstrated best fit with one template Template 44 on an Asian patient IC 1218 This document and the contents hereof are considered proprietary and confidential information of ZELTIQ Aesthetics, Inc. Disclosure to unauthorized individuals or dissemination, publication or copying is prohibited without prior written consent of ZELTIQ.

CoolCurve+ Development Research Patient who is too narrow for CoolCurve (eZ App 6.2) Applicator is able to achieve 4cm of tissue draw with the prototype CoolCurve+ applicator. IC 1218

Performance Study Study conducted by Dr. Eric Bachelor in Pleasanton, CA (April 2012) CoolCurve+ performance was assessed on flank area 25 subjects (BMI ≤ 29) Results assessed at 2 and 4 months Key Findings: No serious adverse events High patient satisfaction IC 1218

High Patient Satisfaction 100% Would Recommend CoolSculpting to a Friend 80% said CoolSculpting met or exceeded expectations IC 1218

Physician Assessment of Fit & Draw CoolCurve+ was compared to CoolCurve applicator to evaluate fit and tissue draw Total of 29 subjects (BMI <25) Assessment performed on the flank Conducted at 3 clinical sites Dr. Henry Chan (Hong Kong) Dr. Joyce Lim (Singapore) Dr. Chih-Hsun Yang (Taiwan) CoolCurve+ on flank 83% had better fit 76% had better draw 14% more patients could be treated who did not have adequate tissue draw with CoolCurve CoolCurve (eZ App 6.2) on flank IC 1218

CoolCurve+ Patient Results Before Treatment on both flanks Procedure by Dr. Henry Chan 3 Months After One CoolSculpting® Treatment IC 1218

CoolCurve+ Patient Results Before Treatment on left flank only Procedure by Dr. Eric Bachelor 4 Months After One CoolSculpting® Treatment +1.4 kg weight change at follow-up visit. IC 1218

CoolCurve+ Patient Results Before Treatment on right flank only Procedure by Dr. Eric Bachelor 4 Months After One CoolSculpting® Treatment No weight change at follow-up visit. IC 1218

CoolCurve+ hands-on exercise Kevin Springer, Clinical Engineering Manager IC 1218

CoolCurve+ White Paper

Thank you! IC 1218