Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb,

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Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb, Hiroshi Miyamoto, MD, PhDc, Kazumi Makishima, MD, PhDa Journal of Allergy and Clinical Immunology Volume 105, Issue 3, Pages 449-454 (March 2000) DOI: 10.1067/mai.2000.104256 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Effects of SEB and TSST-1 on tritiated thymidine incorporation of PBLs (A) , IFN-γ production (B) , IL-4 production (C) , and IL-5 production (D) from PBLs from allergic patients (n = 34) and normal control subjects (n = 15). Statistically significant differences are indicated, as determined by the Mann-Whitney U test. Paired values of allergic patients and control subjects are compared at each SEB and TSST-1 concentration. A, Lymphocyte proliferation. SI was calculated by the ratio of tritiated thymidine incorporation (cpm) of mean stimulated/unstimulated samples. All samples were done in triplicate (*P < .05, **P < .01). B, IFN-γ production (*P < .05, **P < .01). C, IL-4 production (*P < .01). D, IL-5 production (*P < .01). Journal of Allergy and Clinical Immunology 2000 105, 449-454DOI: (10.1067/mai.2000.104256) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 IFN-γ (A) , IL-4 (B) , and IL-5 (C) production from PBLs from allergic patients nasal carriage of S aureus –producing SEB (n = 8), nasal carriage rate of S aureus –producing superantigenic exotoxins other than SEB (n = 6), nasal carriage rate of S aureus not producing superantigenic exotoxins (n = 10), negative nasal carriage rate of S aureus (n = 10), and control subjects (n = 15). For comparison of paired values, the 1-way ANOVA test was used. Journal of Allergy and Clinical Immunology 2000 105, 449-454DOI: (10.1067/mai.2000.104256) Copyright © 2000 Mosby, Inc. Terms and Conditions