From: Development and Characterization of an Adult Retinal Explant Organotypic Tissue Culture System as an In Vitro Intraocular Stem Cell Transplantation.

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From: Development and Characterization of an Adult Retinal Explant Organotypic Tissue Culture System as an In Vitro Intraocular Stem Cell Transplantation Model Invest. Ophthalmol. Vis. Sci.. 2008;49(8):3503-3512. doi:10.1167/iovs.07-1601 Figure Legend: Gross morphology and tissue viability of cultured retinal explants. Retinal explants cultured in B27/N2 or NHS medium were maintained for up to 17 DEV. Wholemount photographs (a) and PI uptake (c) demonstrated that tissue degeneration occurred at the periphery of the explants (↑), whereas the center (#) was spared. Longitudinal quantification of healthy tissue area in explants in B27/N2 medium demonstrated negligible tissue loss through DEV 17, whereas tissue in NHS medium progressively degenerated (b, *P < 0.001 compared with DEV 0 by ANOVA with post hoc Bonferroni comparisons). Scale bar: (a) 6 mm; (c) 400 μm. Date of download: 1/22/2018 The Association for Research in Vision and Ophthalmology Copyright © 2018. All rights reserved.