A, Pyrimethamine serum levels (4 and 24 hours after a dose) of children given 1 mg pyrimethamine per kilogram daily. B, Pyrimethamine serum levels (4 and.

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Presentation transcript:

A, Pyrimethamine serum levels (4 and 24 hours after a dose) of children given 1 mg pyrimethamine per kilogram daily. B, Pyrimethamine serum levels (4 and 24 hours after a dose) of children given 1 mg pyrimethamine per milliliter on Monday, Wednesday, and Friday of each week. Values for children taking phenobarbital are not included. C, Pyrimethamine levels in sera of the entire population of infants taking 1 mg pyrimethamine per kilogram on Monday, Wednesday, and Friday of each week. Values for children taking phenobarbital are not included. D, Pyrimethamine pharmacokinetics and toxicity. E, Toxicity of treatments 1 and 2 was measured as episodes of reversible neutropenia requiring temporary withholding of medications. Although there were no significant differences, there was a trend (p = .09, Fisher exact test, 1 tailed) toward more infants with multiple episodes of reversible neutropenia in the higher-dose group (treatment 2). F, Sulfadiazine hypersensitivity causing skin rash. CSF, cerebrospinal fluid. (A–D, Reproduced with permission from McLeod et al.23 E, Data from McLeod et al.37 F, Reproduced with permission from McLeod et al.162) Source: Toxoplasmosis in the Fetus and Newborn Infant, Neonatology: Clinical Practice and Procedures Citation: Stevenson DK, Cohen RS, Sunshine P. Neonatology: Clinical Practice and Procedures; 2015 Available at: https://accesspediatrics.mhmedical.com/DownloadImage.aspx?image=/data/books/1462/ste_ch57_f020.png&sec=85594659&BookID=1462&ChapterSecID=85594525&imagename= Accessed: January 22, 2018 Copyright © 2018 McGraw-Hill Education. All rights reserved