Edward Peirson Richardson Jr md Neurology resident morning report History of Neurology Edward Peirson Richardson Jr md (1918-1998) March 27th, 2017 Neurology resident morning report

Edward Peirson Richardson Jr md (1918-1998) From a long line of HMS scholars/faculty Father & Paternal Grandfather Chiefs of MGH surgery Mother: Clara Lee Shattuck; he was the 6th Shattuck physician & Shattuck street is where HMS is located. Harvard 1939; HMS 1943 Served in WWII as a physician 1944-46 MGH 1946 Res Pysch under Dr. Stanley Cobb 1947- Queens Square Neurology & Maudsley Hosp for Psychiatry @ Queen Square-exposed to Dr. J. Goodwin Greenfield Neuropathology 1949 @ MGH Asst to Dr. Charles Kubik Neuropathology 1951-Neuropathology lab director, till 1989 Worked with Adams, Miller Fisher, Castlemen, & Victor Continued to work until a few months before his death from lymphoma Bullard Professor of Neuropathology 1984

Edward Peirson Richardson Jr md (1918-1998) MGH residents all did 1 year Neuropathology for many years & were trained by EPR He taught Neuropathology course at HMS for 2nd year med students with RD Adams MD & Alfred Pope MD Also taken by all Neuropathology trainees.(Neurology and Path residents) Frequent contributor to Pathology section of NE Journal of Medicine & CPCs Led Neuropathology teaching sessions/brain cutting during Tuesday evening conferences Neurology. 1967;17(8 Pt 2):22-5

Edward Peirson Richardson Jr md Major contributions Progressive Multifocal Leukoencephalopathy Papers 1961 & 1988 Described what was then a new entity Corticobasal Degeneration Arch Neurol  1968;18:20-33 The myelopathy of pernicious anemia. A neuropathological reappraisal. Acta Neurol Scand. 1968;44:Suppl 5:1-36. Granulomatous angiitis of the central nervous system: protean manifestations and response to treatment 1988; 51(9): 1126–1133.  Granulomatous angiitis of the central nervous system .  Arch Neurol 1968; 19:510-524, The neurological manifestations of systemic lupus erythematosus Medicine 1968 Jul;47(4):337-69. Pathogenesis and evolution of periventricular leukomalacia in infancy .  Arch Neurol 1972;27:229-236 Adreno-leukodystrophy (Sex-Linked Schilder Disease)Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System Arch Neurol 1972;27;458-460 Adrenoleukodystrophy: A clinical and pathological study of 17 cases .  Arch Neurol 1975; 32:577-591 Hallervorden-Spatz syndrome Arch Neurol. 1974 Jan;30(1):70-83. Subacute diencephalic angioencephalopathy .  J Neurol Sci 1974; 22:197-210,

Edward Peirson Richardson Jr md Major contributions Spinal epidural abscess N Engl J Med. 1975 Sep 4;293(10):463-8. Hypoxic-Ischemic Leukoencephalopathy in Man Arch Neurol. 1976;33(1):5-14 Subacute Spongiform Encephalopathy (Creutzfeldt-Jakob Disease Brain 1978 101 (2): 333-344 Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection Neurology1987; 37:562-569 Selective sparing of a class of striatal neurons in Huntington's disease. Science 1985;230;561-563 Neuropathological classification of Huntington's disease J Neuropathol Exp Neurol 1985;44;559-577 Clinical and neuropathologic assessment of severity in Huntington's disease Neurology 1988;38;341-347 Pathology of the Peripheral Nerve (1995) The Neurologic Illness of Eugene O'Neill N Engl J Med 2000; 343:741-742

Letter Written for Dr. Barohn from EP Richardson

Pictures from Tyler Library RD Adams MD E.P. Richardson MD C Miller Fisher, MD Harvey Cushing MD

Elliot Richardson (1920-1999) Who was Elliot Richardson???? Former President of Harvard Former Secretary of State Former Attorney General EP Richardson's Father Answer: Former Attorney General 1973

Elliot Richardson: What is he known for? 1: Allowed minority students in Harvard 2: Helped President Kennedy in Cuban Missile Crises 3: Fired by President Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor 4: Nothing Answer: Fired by Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor Also EP Richardson’s Brother