FAGGI ENRICO S.p.a. Fine Chemicals and Catalysts Division

Fine Chemicals and Catalysts Division Facility in Calenzano (FI) The company Recovery and Refining Facility in Sesto Fiorentino (FI) Fine Chemicals and Catalysts Division Facility in Calenzano (FI) 2

The company The company FAGGI ENRICO S.p.a has been operating into the precious metals field since early 1960 and it occupies a surface area of about 3500 m2. Originally FAGGI ENRICO S.p.a. started its activity as precious metal recovery and refining facility. From mid 1970’s has been created the fine chemicals division specialized in the production of precious metals compounds. 3

The company In 2013, FAGGI ENRICO S.p.a, located in Sesto Fiorentino, established a new Fine Chemicals and Catalysts Division in Calenzano. The 2000 m2 manufacturing site provides platinum group metal (PGM) catalysts for synthestic processes of fine chemicals and pharmaceuticals industries. Development, caractherization and testing of new catalysts are performed in our R&D department. The flexible manufacturing platform consist of a pilot plant and full scale commercial production facility. In addition analytical laboratories provides the quality control of all raw materials, in process and finished products. 4

Authorizations and Certifications Authorization for storage, transport and recovery of precious metals from spent catalysts UNI EN ISO 14001:2004 certification BS OHSAS 18001:2007 (Safety Management System for recovery and production of chemicals containing precious metal) Establishment of an environmental management system according to EMAS regulation (2005) 5

1 gloves box under nitrogen for drying and packaging operations Production plant Production area for homogeneous catalysts: 5 stainless steel and glass lined reactors up to 200 litres 1 glass crystallizer 100 litres and 2 filter under vacuum 1 gloves box under nitrogen for drying and packaging operations 6

Production plant Production area for heterogeneus catalysts: 5 stainless steel and glass lined reactors up to 200 litres 2 stainless steel and glass lines reactors up to 3500 liters 1rotary vacuum filter 1static dryer 7

R&D and Analytical Laboratories The R&D and analytical laboratories are equipped with the following instrumentation: Modular reaction systems with glass vessels from 0.5 L up to 3 L High pressure reactor with glass and steel vessels from 250 ml up to 1 L for hydrogenation and catalyst testing Inductively coupled plasma optical emission spectroscopy ICP-OES X ray fluorescence spectroscopy High Performance Liquid Chromatography HPLC 8

Highly qualified staff Highly qualified personnel in collaboration with Chemical Institute of Organometallic compound (ICCOM-CNR) and Organic chemistry Department of University of Florence guarantee development and production of high technology catalysts. 9

Our services Development of new catalysts tailored to customer demands Catalyst testing on different catalytic reactions under a wide range of conditions Production of standards and custom catalysts on industrial scale (capacity: from kg to ton quantities) Treatment of spent catalysts and precious metal (Pt, Pd, Ag, Au, Rh, Ru) recovery through a recycling method minimising precious metal loss (capacity: 50-100 tons/year of spent catalyst solution) 10

Heterogeneous Catalyst Reactions / PORTFOLIO Our portfolio contains suitable catalysts for the following reactions: Hydrogenation of C=C doubles bond, carbonyls, nitriles, nitro groups and aromatic rings Reductive alkylation, reductive aminations O-debenzylation, N-debenzylation Deprotection of carbobenzyloxy group Hydrodehalogenation Rosemund reduction Oxidation dehydrogenation of alcohols and sugar 11

Homogeneous Catalyst Reactions / PORTFOLIO Our portfolio contains suitable Pd based catalysts for the following cross coupling reactions: Suzuky C-C Coupling of aryl or vinyl boronic acid with aryl halide R1 : aryl, vinyl - X : I > triflate > Br Sonogashira C-C Coupling of terminal alkyne and aryl or vinyl halide R2 : aryl, vinyl - X : I > triflate > Br 12

Homogeneous Catalyst Reactions / PORTFOLIO Heck C-C Coupling of aryl or alkenyl halide with olefine R : aryl, alkenyl - X : I > triflate > Br Still C-C Coupling of organohalides with organostannanes X : halide, triflate - polar solvent : DMSO, DMF Buchwald-Hartwig C-N Coupling of aryl or alkyl halide and alkyl amines X : halide, triflate - R2 : alkyl, aryl and R3 : H, alkyl, aryl 13

Products HETEROGENEOUS PGM CATALYSTS Palladium 5% carbon powder Platinum 5% carbon powder Platinum 10% carbon powder Rhodium 5% carbon powder Rutenium 5% carbon powder 14

Products HOMOGENEUS PD CATALYSTS Tetrakis(triphenylphosphine)palladium(0) Pd(PPh3)4 CAS : 14221-01-3 Dichlorobis(triphenylphosphine)palladium(II) PdCl2(PPh3)2 CAS : 13965-03-2 Dichloro[1,2-bis(diphenylphosphino)ethane]palladium(II) PdCl2(dppe) CAS : 19978-61-1 Dichloro[1,1’-bis(diphenylphosphino)ferrocene]palladium(II) PdCl2(dppf) CAS : 95408-45-0 15

Products HOMOGENEOUS PD PRECURSORS Palladium(II) acetate (trimer) [Pd(OAc)2]3 CAS : 3375-31-3 Palladium(II) chloride PdCl2 CAS : 7647-10-1 HOMOGENEUS PD CATALYSTS UNDER DEVELOPMENT Pd complexes with different phosphine ligands Pd precursors 16

Contacts 13 FINE CHEMICALS AND CATALYSTS DIVISION FAGGI ENRICO S.p.a. Via del Pescinale 73 50041 Calenzano (Fi) Tel. +39 055.8877522 Contact name: Marco Possenti Cell. +39 3667789641 Email: marco.possenti@faggi.it RECOVERY AND REFINING DIVISION Via Ettore Majorana 101/103 50019 Sesto Fiorentino (Fi) Tel. +39 055.311861 Fax +39 055.311791 Email: info@faggi.it 13