Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study Colin B. Brown,

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Presentation transcript:

Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study Colin B. Brown, M.D., F.R.C.P., Anthony A. Luciano, M.D., Dan Martin, M.D., Elizabeth Peers, Ph.D., Alison Scrimgeour, M.Sc., Gere S. diZerega, M.D. Fertility and Sterility Volume 88, Issue 5, Pages 1413-1426 (November 2007) DOI: 10.1016/j.fertnstert.2006.12.084 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Study procedure flow. Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Clinical success. The percentage of patients in whom the number of sites with adhesions decreased by at least three or 30% of the number of sites lyzed (PP population; P=.018 between groups). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Clinical success in infertility patients (PP population; P=.0007). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Percentage of patients free of de novo adhesions in the Adept and LRS treatment groups at second laparoscopy (PP population; P=.029). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 5 Percentage of infertility patients with a reduction in AFS score at second laparoscopy (PP population; P=.001). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 6 Percentage of patients with primary diagnosis of infertility and endometriosis with a reduction in AFS score at second laparoscopy (PP population; P=.003). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 7 Percentage of patients with primary diagnosis of infertility and pelvic pain with a reduction in AFS score at second laparoscopy (PP population; P=.006). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 8 Clinical success in patients with increased adhesion burden (PP population). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 9 Clinical success in patients with endometriosis according to number of sites treated for endometriosis (PP population). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 10 Odds ratio plot with 95% confidence interval (95.2% for clinical success) for each of the study parameters (PP population). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

Figure 11 Odds ratio plot with 95% confidence interval (95.2% for success) for clinical success and AFS scores in infertility patients (PP population). Brown. Adept reduces adhesions in laparoscopy. Fertil Steril 2007. Fertility and Sterility 2007 88, 1413-1426DOI: (10.1016/j.fertnstert.2006.12.084) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions