Volume 131, Issue 4, Pages (April 2007)

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Volume 131, Issue 4, Pages 993-999 (April 2007) Significance of Extranodal Extension of Regional Lymph Nodes in Surgically Resected Non-small Cell Lung Cancer Yung-Chie Lee, MD, PhD, Chen-Tu Wu, MD, Shuenn-Wen Kuo, MD, Yu-Ting Tseng, MD, Yih-Leong Chang, MD CHEST Volume 131, Issue 4, Pages 993-999 (April 2007) DOI: 10.1378/chest.06-1810 Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 1 Metastatic NSCLC in an LN with extranodal extension (hematoxylin-eosin, original ×33). CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 2 Comparison of survival curves between the presence and absence of extranodal extension (p < 0.001). CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 3 Survival curves in three groups with different total numbers of positive extranodal LN (ie, 0, 1 to 3, and >3) [p < 0.001]. CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 4 Survival curves in three groups with different positive rates of extranodal extension (ie, 0%, ≤ 50%, and >50%) [p < 0.001]. CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 5 Survival curves in different tumor stages with consideration of extranodal extension. Significant difference between stage IIIA extranodal (−) and stage II extranodal (+) was noted (p < 0.001). CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

Figure 6 Survival curves in three groups with either or both intrapulmonary and mediastinal extranodal extension (p = 0.069). CHEST 2007 131, 993-999DOI: (10.1378/chest.06-1810) Copyright © 2007 The American College of Chest Physicians Terms and Conditions