Relationship between early recurrence and micrometastases in the lymph nodes of patients with stage I non-small-cell lung cancer Riichiroh Maruyama,

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Relationship between early recurrence and micrometastases in the lymph nodes of patients with stage I non-small-cell lung cancer Riichiroh Maruyama, MDa, Kenji Sugio, MDa, Tetsuya Mitsudomi, MDb, Genkichi Saitoh, MDa, Teruyoshi Ishida, MDc, Keizo Sugimachi, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 114, Issue 4, Pages 535-543 (October 1997) DOI: 10.1016/S0022-5223(97)70041-2 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 A, Section of the lymph node regional to primary lung adenocarcinoma. A single CK-positive tumor cell is seen against a background of benign lymph nodes cells by means of the strept-avidin-biotin complex immunoperoxidase technique with a monoclonal CK antibody and methyl-green counterstaining. B, A comparable section from the same lymph nodes as depicted in A, stained by HE. No tumor cells are visible in this routine preparation. (Original magnifications ×80.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 A, Section of the lymph node regional to primary lung adenocarcinoma. A single CK-positive tumor cell is seen against a background of benign lymph nodes cells by means of the strept-avidin-biotin complex immunoperoxidase technique with a monoclonal CK antibody and methyl-green counterstaining. B, A comparable section from the same lymph nodes as depicted in A, stained by HE. No tumor cells are visible in this routine preparation. (Original magnifications ×80.) The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 A, The distribution of CK-positive tumor cells in the lymph nodes of T1 disease. B, The distribution of CK-positive tumor cells in the lymph nodes of T2 disease. The open squares indicate lymph nodes that were not examined, the hatched squares represent the CK-negative lymph nodes, and the closed squares denote the CK-positive lymph nodes. The numbers assigned to the regional nodal stations are as follows: number 1 indicates the highest mediastinal nodes, number 2 the paratracheal nodes, number 3 the pretracheal nodes, number 4 the tracheobronchial angle nodes, number 5 Botallo's nodes, number 6 the paraaortic (ascending aorta) nodes, number 7 the subcarinal nodes, number 8 the paraesophageal nodes, number 9 the pulmonary ligament nodes, number 10 the hilar nodes, number 11 the interlobar nodes, and number 12 the lobar nodes.28 The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 A, The distribution of CK-positive tumor cells in the lymph nodes of T1 disease. B, The distribution of CK-positive tumor cells in the lymph nodes of T2 disease. The open squares indicate lymph nodes that were not examined, the hatched squares represent the CK-negative lymph nodes, and the closed squares denote the CK-positive lymph nodes. The numbers assigned to the regional nodal stations are as follows: number 1 indicates the highest mediastinal nodes, number 2 the paratracheal nodes, number 3 the pretracheal nodes, number 4 the tracheobronchial angle nodes, number 5 Botallo's nodes, number 6 the paraaortic (ascending aorta) nodes, number 7 the subcarinal nodes, number 8 the paraesophageal nodes, number 9 the pulmonary ligament nodes, number 10 the hilar nodes, number 11 the interlobar nodes, and number 12 the lobar nodes.28 The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 The disease-free survival curves by the restaged N factor. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 The survival curves by the restaged N factor. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 A, The survival of patients with pathologic N1 disease and N1 disease restaged by CK. B, The survival of patients with pathologic N2 disease and N2 disease restaged by CK. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 A, The survival of patients with pathologic N1 disease and N1 disease restaged by CK. B, The survival of patients with pathologic N2 disease and N2 disease restaged by CK. The Journal of Thoracic and Cardiovascular Surgery 1997 114, 535-543DOI: (10.1016/S0022-5223(97)70041-2) Copyright © 1997 Mosby, Inc. Terms and Conditions