From: Herpes Zoster and Recurrent Herpes Zoster

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From: Herpes Zoster and Recurrent Herpes Zoster Figure 1. Population data related to herpes zoster (HZ) in Miyazaki Prefecture. Horizontal and vertical axes indicate the age and number of patients, respectively. (A) The total population of Miyazaki Prefecture was 1.12 million, including 525 317 men and 594 595 women, based on census data from 2009 to 2015. (B) The 34 877 patients with HZ from June 2009 to November 2015. Of the 34 877 patients with clinical diagnosis of HZ, the mean number of patients with HZ per year increased at ≥50 years, with women being more affected than men in that age group. (C) The age- and gender-dependent distribution of 2438 polymerase chain reaction (PCR)-diagnosed patients with HZ. The distribution of patients with PCR-diagnosed HZ was similar to that of patients with clinical diagnosis of HZ shown in B. (D) The age- and gender-dependent distribution of 1076 patients with recurrent HZ among a total of 16 784 patients with HZ. The number of patients with recurrent HZ per year increased with age, and the ratio of female patients with recurrent HZ was much more than that of HZ shown in B. Male and female populations are shown in blue and red columns, respectively. From: Herpes Zoster and Recurrent Herpes Zoster Open Forum Infect Dis. 2017;4(1). doi:10.1093/ofid/ofx007 Open Forum Infect Dis | © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

From: Herpes Zoster and Recurrent Herpes Zoster Figure 2. The age-dependent herpes zoster (HZ) incidences per 1000 person-years and HZ-naive and HZ-experienced population in Miyazaki Prefecture and the population of Miyazaki Prefecture was used as the denominator. (A) The age-dependent incidences per 1000 person-years of the total, male, and female patients are shown by black, blue, and red lines, respectively, and the incidence (per 1000 person-years) of HZ (solid line) and HZ recurrence ([Rec] dashed line) increased at age 50 years and older, with female patients being more affected than male patients in that age group. (B) Herpes zoster-naive and HZ-experienced populations are shown as open and closed columns, respectively. For each age group, the proportion (%) of HZ-naive population is indicated below the age group. The ratio of HZ-experienced persons increased with age, and the HZ-experienced population exceeded one third before the age of 80 years. (C) The age-dependent incidences of initial HZ in the HZ-naive population and recurrent HZ in the HZ-experienced population are shown as solid and dashed lines, respectively. The incidence of recurrent HZ was low but showed a small peak at the age of 60–69 years, with 2.31 per 1000 person-years. The incidence of initial HZ increased with age up to 11.5 per 1000 person-years at the age of 80–89 years. From: Herpes Zoster and Recurrent Herpes Zoster Open Forum Infect Dis. 2017;4(1). doi:10.1093/ofid/ofx007 Open Forum Infect Dis | © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

From: Herpes Zoster and Recurrent Herpes Zoster Figure 3. The ages at the initial and recurrent episodes of herpes zoster (HZ), and the interval between episodes. The figures show the profile of the ages and gender of initial and recurrent HZ and their interval. The difference in the peak age between male and female are noted, and the median and mean intervals were 10 and 14 years, respectively. (A) The ages at the initial (solid line) and recurrent (dashed line) HZ episodes of the total, male, and female patients are expressed as black, blue, and red lines. The episode before the recurrent episode was included as the initial episode in patients with 2 and 3 recurrences. The difference in the peak age between male and female are noted. (B) The cases are shown according to the sex-dependent interval length between the initial (prior) and recurrent episodes in the total, male, and female patients as black, blue, and red lines, respectively. (C) The intervals of the number of patients who experienced recurrences in different dermatomes and in the same dermatome are shown by the black solid line and black dashed line, respectively. From: Herpes Zoster and Recurrent Herpes Zoster Open Forum Infect Dis. 2017;4(1). doi:10.1093/ofid/ofx007 Open Forum Infect Dis | © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

From: Herpes Zoster and Recurrent Herpes Zoster Figure 4. A total of 1905 cases in 1076 patients with recurrent herpes zoster (HZ) occurred both in different dermatomes and in the same dermatome. There was no difference between left and right in the distribution even between men and women, but the left dermatomes were significantly more affected than right dermatomes in patients with recurrence in the same dermatome. The (1) right and left dermatomes and (2) a single dermatome and multiple dermatomes are summarized in the box. Segmental innervations of dermatomes are indicated as trigeminal (V), cervical (C), thoracic (T), lumbar (L), and sacral (S) nerves, and single and multiple dermatomes are separated by white and dark boxes, respectively. (A) The distribution of a total of 1905 dermatomes is shown, and 1 otherwise healthy patient who experienced HZ duplex bilateralis at Th5 and Th6 at the age of 27 years is indicated in red. The distribution of dermatomes in patients with HZ in different dermatomes (B) and in the same dermatome (C) is shown. Recurrence in the same dermatome showed a significant preference for the left side in the comparison of dermatomal distribution in patients with recurrence (odds ratio, 1.31; 95% confidence interval, 1.03–1.66; P = .027, by the χ<sup>2</sup> test). From: Herpes Zoster and Recurrent Herpes Zoster Open Forum Infect Dis. 2017;4(1). doi:10.1093/ofid/ofx007 Open Forum Infect Dis | © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com