Skin Pharmacol Physiol 2017;30: DOI: /

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Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Fig. 1. After 7 days of UVA irradiation, 90% human dermal fibroblasts (HDF) presented increased expression of senescence-associated β-galactosidase. In the control group, however, the rate of positively staining fibroblasts was <20%. ×40. a HDF irradiated with UVA for 7 days. b HDF without irradiation (control group). © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Fig. 2. After 7 days of UVA irradiation, the expression of p16/INK-4a and p21/WAF-1 proteins was increased in Western blot analysis. The protein level was normalized to β-actin. a p16/INK-4a. b p21/WAF-1. © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Fig. 3. Differentially expressed lncRNA profile and unsupervised cluster. a Gene expression: control vs. UV irradiation. FDR ≤ 0.001 AND log2 ratio ≥1. High-throughput sequencing showed that in the HDF group with repeated UVA irradiation, 1,730 lncRNA exhibited over 2-fold expression changes compared to the control group. Among these 1,494 lncRNA were upregulated, while 236 were downregulated after 7 days of UVA irradiation (reads per thousand base pairs per million reads). DET, differentially expressed transcripts. b Unsupervised cluster of differentially expressed lncRNA. © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Fig. 4. Differentially expressed lncRNA- related protein coding genes in chronic UVA-treated human dermal fibroblasts were analyzed using Gene Ontology (GO) database (http://www.geneontology.org). GO significant enrichment analysis showed these differently expressed lncRNA are mainly involved in cell division, molecular function, and biological process, which are related with chronic UVA damaging mechanisms. © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Fig. 5. Molecular pathway analysis revealed that chronic UVA-induced changes in lncRNA were mainly involved in the PI3K-Akt signaling pathway, cytokine-cytokine receptor interaction pathway, focal adhesion, signaling pathways regulating pluripotency of stem cells, and pathways in cancer. ECM, extracellular matrix. © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Table 1. qRT-PCR Primers © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Table 2. Changes in lncRNA expression (UV vs. control) induced by repeated UVA irradiation © 2017 S. Karger AG, Basel

Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts Skin Pharmacol Physiol 2017;30:315-323 - DOI:10.1159/000477972 Table 3. lncRNA target prediction by Gene Ontology © 2017 S. Karger AG, Basel