Figure 1. Cellular distribution of a disintegrin and metalloproteinases (ADAM)-9 expression in hepatocellular carcinoma (HCC) and non-tumorous liver tissues.

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Figure 1. Cellular distribution of a disintegrin and metalloproteinases (ADAM)-9 expression in hepatocellular carcinoma (HCC) and non-tumorous liver tissues (original magnification ×400). (A) ADAM-9-negative staining was seen in non-tumorous liver tissues. (B) ADAM-9-positive staining was indicated by numerous yellowish granules in the cytoplasmic and membrane cellular compartment of tumor cells. (C) Representative ADAM-9-negative case of HC; normal bile duct cells indicate positive immunostaining for ADAM-9, as an internal positive control. (BD, bile duct). From: Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis Jpn J Clin Oncol. 2010;40(7):645-651. doi:10.1093/jjco/hyq030 Jpn J Clin Oncol | © The Author (2010). Published by Oxford University Press. All rights reserved 1