Down-Regulation of Annexin A10 in Hepatocellular Carcinoma Is Associated with Vascular Invasion, Early Recurrence, and Poor Prognosis in Synergy with.

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Down-Regulation of Annexin A10 in Hepatocellular Carcinoma Is Associated with Vascular Invasion, Early Recurrence, and Poor Prognosis in Synergy with p53 Mutation Shu-Hsiang Liu, Chiao-Ying Lin, Shian-Yang Peng, Yung-Ming Jeng, Hung-Wei Pan, Po-Lin Lai, Chao-Lien Liu, Hey-Chi Hsu The American Journal of Pathology Volume 160, Issue 5, Pages 1831-1837 (May 2002) DOI: 10.1016/S0002-9440(10)61129-7 Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 1 Northern blot for ANXA10 using a cDNA fragment cloned from differential display as probe. ANXA10 mRNA (A10) of 1.4 kb was detected in the livers (L) and dramatically decreased in HCC (T) in five cases. The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 2 RT-PCR of ANXA10 mRNA in paired HCC and liver. ANXA10 mRNA (A10) was dramatically decreased in HCC (T) in 16 of 22 representative cases. Stage, tumor stage (I to IV); size, tumor size (cm). The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 3 Northern blot analysis of ANXA10 in multiple adult tissues. The commercially obtained Hybond Northern blot (Amersham) containing polyA+ RNAs was hybridized with a 1.2-kb cDNA fragment containing the whole coding region and 3′-UTR of ANXA10. A single ANXA10 transcript of ∼1.3 kb (arrowhead) was identified in adult liver alone. The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 4 Expression of ANXA10 in multiple adult and fetal tissues. ANXA10 mRNA (A10) was expressed in abundance in adult and fetal stomach, in low level in adult pancreas, but undetectable in most adult tissues and fetal tissues. The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 5 Expression of ANXA10 in other malignant tumors. ANXA10 mRNA (A10) was detected in focal nodular hyperplasia (FNH), but not in hepatoblastoma (HB), cholangiocarcinoma (CH), metastatic colon carcinoma (M), lung carcinoma (399, adenosquamous cell carcinoma; 544, squamous cell carcinoma; 546, spindle cell cancer), breast carcinoma, and ovarian carcinoma (926, 950, endometrioid carcinoma; 916, serous cystadenocarcinoma; 922, 928, adenocarcinoma; 924, yolk sac tumor; 945, mucinous cystadenocarcinoma; 933, clear cell carcinoma). The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 6 Cumulative survival in HCC in relation to ANXA10 mRNA expression. A decreased ANXA10 (D) expression had a lower 4-year survival than normal expression (N), P = 0.0014 (log-rank test). The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions

Figure 7 Cumulative survival in HCC in relation to normal (N) or decreased (D) expression of ANXA10 and presence (+) or absence (−) of p53 mutation. HCC with decreased ANXA10 expression and p53 mutation had the lowest 4-year survival, P = 0.0025 (log-rank test). The American Journal of Pathology 2002 160, 1831-1837DOI: (10.1016/S0002-9440(10)61129-7) Copyright © 2002 American Society for Investigative Pathology Terms and Conditions