From: Effective Arrestin–Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis Trans. Vis. Sci. Tech.. 2013;2(2):1. doi:10.1167/tvst.2.2.1 Figure Legend: Cytokine concentration in arrestin-stimulated splenocyte cultures obtained from vehicle- and RTL351-treated HLA-DR3+ Tg mice injected with arrestin. Splenic cells (collected 35 days PI) were stimulated with arrestin and Arr291–310 for 48 hours and multiple cytokines were quantitated by the multiplex ELISA system. Bar graphs represent only cytokines that show significant changes in response to RTL351 treatment in mice. (A) Inflammatory cytokines IL-2, IL-17, IFN-γ, and IL-6; (B) anti-inflammatory cytokines IL-4, IL-5, IL-10, and IL-13; (C) inflammatory chemokines RANTES and MIP-1α. Bars represent the mean cytokine concentration of three mice per group representative of two individual experiments (mean ± SEM). Statistical differences were calculated using a Mann-Whitney U test; *P < 0.05, **P < 0.01. Black bar = vehicle treatment, gray bar = RTL351 treatment. Date of download: 3/1/2018 The Association for Research in Vision and Ophthalmology Copyright © 2018. All rights reserved.