Figure 1 Annual number of isolates of imipenem-resistant P. aeruginosa

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Figure 1 Annual number of isolates of imipenem-resistant P. aeruginosa Figure 1 Annual number of isolates of imipenem-resistant P. aeruginosa. Annual number of MDR P. aeruginosa (MDRP) or MBL-producing strains in imipenem-resistant strains and annual number of MBL-producing strains in MDR P. aeruginosa strains are shown. Pa, P. aeruginosa. Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the blaIMP-1 gene cassette in Hiroshima J Antimicrob Chemother. 2009;64(1):46-51. doi:10.1093/jac/dkp142 J Antimicrob Chemother | © The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Figure 2 Schematic representation of the genetic content in the bla<sub>IMP-1</sub> and bla<sub>VIM-2</sub> integrons. ORFs are shown as arrows indicating the orientation of the coding sequence and with the gene name. Open ellipses, attI1 site; black circles, 59 bp elements/attC; intl1, integrase; aac, aminoglycoside acetyltransferase; aad, aminoglycoside adenyltransferase; qacEΔ1, QacEΔ1 multidrug exporter; sul, Sul1 dihydropteroate synthase; orf5, hypothetical protein; and IS, insertion sequence. Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the blaIMP-1 gene cassette in Hiroshima J Antimicrob Chemother. 2009;64(1):46-51. doi:10.1093/jac/dkp142 J Antimicrob Chemother | © The Author 2009. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org