From: A Simulation Study of Common Propofol and Propofol-Opioid Dosing Regimens for Upper Endoscopy:Implications on the Time Course of Recovery Anesthes. 2012;117(2):252-262. doi:10.1097/ALN.0b013e31825fb1b2 Figure Legend: represent drug concentration pairs that produce 5% probabilities of loss of responsiveness and respiratory compromise. Numbers represent time (in minutes) to recovery, defined as a probability of effect less than 5%, and are placed next to the corresponding washout curve and isobole. Date of download: 3/2/2018 Copyright © 2018 American Society of Anesthesiologists. All rights reserved.