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Bridging the Gap between Academia and Industry: Model for drug development in Brazil Biopharmaceutical SA Thomas Gerlach PhD

INNOVATION is global and happens everywhere BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. INNOVATION is global and happens everywhere Situation in Brazil today High Discovery Brazil world share of science publications is 2.2% (growth 32%) (2008-2014) Low patent Brazil world share of USPTO patents was 0.1% in 2008 and 2014 (0% growth) Innovation occurs in countries independent of their wealth UNESCO SCIENCE REPORT TOWARDS 2030) (2015)

BIGGEST CHALLENGE OF THE LIFE SCIENCES SECTOR BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. BIGGEST CHALLENGE OF THE LIFE SCIENCES SECTOR The drug development process starting from research to commercialization is challenging as it is long, risky and expensive Bridging the gap between academia and industry is difficult UNESCO SCIENCE REPORT TOWARDS 2030) (2015)

Discovery & Preclinical BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. PROFILE OF INVESTORS IN GLOBAL DRUG DEVELOPMENT Clinical Discovery & Preclinical Regulatory Approval Innovation Phase I Phase II Phase III PHARMA Problem: Death Valley PHARMA PHARMA ACADEMIC PHARMA PUBLIC INV. PUBLIC INV. VENTURE CAPITAL PHARMA VENTURE CAPITAL VENTURE CAPITAL GOVERN. PUBLIC INV. ACADEMIC ACADEMIC PUBLIC INV. VENTURE CAPITAL GOVERN. GOVERN. ACADEMIC VENTURE CAPITAL ACADEMIC GOVERN. GOVERN.

BRIDGING THE COMMERCIALIZATION GAP BETWEEN ACADEMIA AND INDUSTRY BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. ABOUT BIOZEUS BRIDGING THE COMMERCIALIZATION GAP BETWEEN ACADEMIA AND INDUSTRY BIOZEUS was created by a Brazilian venture capital fund FinHealth… ...to translate promising innovative health research projects into new therapies that reach the global market We license early-stage technologies from universities and research institutions and then develop them with the oversight of our experienced team and network of partners until proof of concept.

BUSSINESS DEVELOPMENT DEVELOPMENT SELECTION ACCESS BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. BIOZEUS main activities BUSSINESS DEVELOPMENT Partnership with biotech and pharma companies DEVELOPMENT SEVEN projects in-licensed To lower risk and maximize the value of the asset SELECTION ANY therapeutic area Analyzed more than 500 projects from academia ACCESS Partnership with more than 60 Brazilian institutes Constant access to new research groups

BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. How BIOZEUS works Selection and in-licensing promising Brazilian academic projects; Expertise in translation of scientific research into human drugs; Funding (coordinate multiple private and public funding sources); Experienced project management; Reach out to potential pharmaceutical and biotechnology industry partners/ licensees.

BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. GENERATING VALUE

BIOZEUS selecting criteria Copyright ©2014 BIOZEUS. All Rights Reserved. SELECTING PROJECTS BIOZEUS selecting criteria Good science addressing a real and global medical need Isolated and characterized compound; Mechanism of action elucidated Possibility of international patent protection Working across all therapeutic areas

BIOZEUS is not limited to a specific therapeutic area Copyright ©2014 BIOZEUS. All Rights Reserved. SELECTING PROJECTS BIOZEUS is not limited to a specific therapeutic area

DEVELOPMENT: TEAM SELECTION BIOZEUS Copyright ©2014 BIOZEUS. All Rights Reserved. DEVELOPMENT: TEAM SELECTION CMC ADME PD TOX CLINICAL TRIAL REGULATORY PATENT MARKET

BIOZEUS ROLE IN INNOVATION IN BRAZIL Copyright ©2014 BIOZEUS. All Rights Reserved. BIOZEUS ROLE IN INNOVATION IN BRAZIL Publicly funded research at Brazilian universities is generating every year discovery research and identification and validation of lead compounds for new drugs. The university has not the expertise nor the funding to advance development beyond the early stages and most innovations are lost and will never be commercialized. Biozeus bridges this commercialization gap by bringing together publicly funded health research, government and private investment and the pharmaceutical/ biotechnology industry. Biozeus is helping to transform public investment in discovery research into viable commercial opportunities and will help to foster innovation in the pharmaceutical segment in Brazil.

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