Interaction between antioxidants in the lipid phase (cell membranes) and the aqueous phase (cytosol). (R•, free radical; PUFA-OO•, peroxyl radical of polyunsaturated.

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Presentation transcript:

Interaction between antioxidants in the lipid phase (cell membranes) and the aqueous phase (cytosol). (R•, free radical; PUFA-OO•, peroxyl radical of polyunsaturated fatty acid in membrane phospholipid; PUFA-OOH, hydroxyperoxy polyunsaturated fatty acid in membrane phospholipid, released into the cytosol as hydroxyperoxy polyunsaturated fatty acid by the action of phospholipase A2; PUFA-OH, hydroxy polyunsaturated fatty acid; Toc-OH vitamin E [α-tocopherol]; TocO•, tocopheroxyl radical; Se, selenium; GSH, reduced glutathione; GS-SG, oxidized glutathione, which is reduced to GSH after reaction with NADPH, catalyzed by glutathione reductase; PUFA-H, polyunsaturated fatty acid.) Source: Chapter 44. Micronutrients: Vitamins & Minerals, Harper's Illustrated Biochemistry, 29e Citation: Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil P. Harper's Illustrated Biochemistry, 29e; 2012 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/murr29/murr29_c044f006.png&sec=40146757&BookID=389&ChapterSecID=40142524&imagename= Accessed: March 02, 2018 Copyright © 2018 McGraw-Hill Education. All rights reserved

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