Tissue Lipid Peroxidation and Reduced Glutathione Depletion in Hypochlorite-Induced Lung Injury  Stefan Hammerschmidt, MD, Nicole Büchler, Hans Wahn, MD  CHEST  Volume 121, Issue 2, Pages 573-581 (February 2002) DOI: 10.1378/chest.121.2.573 Copyright © 2002 The American College of Chest Physicians Terms and Conditions

Figure 1 Hypochlorite-induced pressure response. Upper panel: course of the increase in PAP due continuous infusion of hypochlorite over time. Lower panel: comparison of baseline PAP (PAPt = 0 min) and PAPmax of all experimental groups (*p < 0.05 vs c-105). CHEST 2002 121, 573-581DOI: (10.1378/chest.121.2.573) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

Figure 2 Mean total recording (ttot) and mean time of PAPmax (tpapmax) of all experimental groups are compared (*p < 0.05 vs c-105). CHEST 2002 121, 573-581DOI: (10.1378/chest.121.2.573) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

Figure 3 Tissue concentration of rGSH and of free functional sulfhydryl (SH) groups (upper panel) and the tissue concentration of the LPO products malonaldehyde and 4-hydroxyalkenals (lower panel) of all experimental groups are shown (*p < 0.05 vs both controls). CHEST 2002 121, 573-581DOI: (10.1378/chest.121.2.573) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

Figure 4 Parameters of lung injury, ie,Δ PAPmax (upper panels) and Kf,cmax (lower panels), of the 500 nmol/min, 1,000 nmol/min, and 2,000 nmol/min HOCl groups are plotted against the corresponding tissue rGSH concentration of each individual experiment. The left column summarizes these correlations of the data for all three groups. The correlation coefficient and its p value are given. CHEST 2002 121, 573-581DOI: (10.1378/chest.121.2.573) Copyright © 2002 The American College of Chest Physicians Terms and Conditions

Figure 5 Parameters of lung injury, ie,Δ PAPmax (upper panels) and Kf,cmax (lower panels), of the 500 nmol/min, 1,000 nmol/min, and 2,000 nmol/min HOCl groups are plotted against the corresponding tissue LPO product concentration of each individual experiment. The correlation coefficient and its p value are given. CHEST 2002 121, 573-581DOI: (10.1378/chest.121.2.573) Copyright © 2002 The American College of Chest Physicians Terms and Conditions