Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy Saidan Ding 1 ;Jianjing Yang.

Slides:



Advertisements
Similar presentations
Ischemia-induced Angiogenesis is Attenuated in Aged Rats
Advertisements

Ischemia-induced Angiogenesis is Attenuated in Aged Rats
Ischemia-induced Angiogenesis is Attenuated in Aged Rats
Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1 Li Yun;Mei Zhu;Liu Shuiqiao;Wang Tong;Li Hui;Li Xiao-Xiao;Han.
LW-AFC Effects on N -glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer#cod#x02019;s Disease Wang Jianhui 1, 2 ;Cheng.
LW-AFC Effects on N -glycan Profile in Senescence-Accelerated Mouse Prone 8 Strain, a Mouse Model of Alzheimer#cod#x02019;s Disease Jianhui Wang 1, 2,
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Cai Mengfei 1 ;Zhang Wenting.
Relationship of Circulating CXCR4 + EPC with Prognosis of Mild Traumatic Brain Injury Patients Yunpeng Lin 1, # ;Lan Lan Luo 2, # ;Jian Sun 1 ;Weiwei.
Fig. 3. Expression of Ninj1protein in cortices of the ischemic hemispheres of the rat brain at 4 day post-MCAO. Coronal brain sections were prepared at.
Shining the Light on Senescence Associated LncRNAs
Jing Dong 1 ;Xin Ma 1 ;Jingyuan Qie 1 ;Xunming Ji 2 ;
Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice Zhang Chengjie 1, 2, 3 ;Zhu Yanbing 2 ;Wang Song 2, 3 ;Zachory Wei Zheng 1, 2,
Deyong Lv 1, 2, 3 ;Jingbo Li 4 ;Hongfu Li 3 ;Yu Fu 5 ;Wei Wang 1, 2 ;
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway Zhang Meng 1 ;Deng Yong-Ning 1 ;Zhang.
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer#cod#x02019;s Disease and Related Tauopathies L Castillo-Carranza Diana 1, 2 ;N Nilson.
CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain Zhang Lin-Yuan 1 ;Lin #cod#x0002A;Pan 2 ;Pan Jiaji 3 ;Ma.
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer#cod#x02019;s Disease and Related Tauopathies Diana L Castillo-Carranza 1, 2 ;Ashley N.
The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice Zhao Guangxian 1 ;W. Cheng Xian 1, 7, 8 ;Piao Limei 1, 2 ;Hu Lina.
Yang Changjun;M. DeMars Kelly;Candelario-Jalil#cod#x0002A; Eduardo;
Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer#cod#x02019;s Disease Zohara Sternberg 1 ;Zihua Hu 2 ;Daniel Sternberg 1 ;Shayan.
Diagnostic and Immunosuppressive Potential of Elevated Mir-424 Levels in Circulating Immune Cells of Ischemic Stroke Patients Li Guangwen 1, 2 ;Ma Qingfeng.
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway Zhang Meng 1 ;Deng Yong-Ning 1 ;Zhang.
Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1 Yun Li;Zhu Mei;Shuiqiao Liu;Tong Wang;Hui Li;Xiao-Xiao.
Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy Ding Saidan 1 ;Yang Jianjing.
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer#cod#x02019;s Disease and Related Tauopathies Diana L Castillo-Carranza 1, 2 ;Ashley N.
Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua.
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer#cod#x02019;s Disease and Related Tauopathies Diana L Castillo-Carranza 1, 2 ;Ashley N.
Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP Liu Xiangrong 1, 2, 3 ;Wen Shaohong 1, 2,
Role of Pro-Inflammatory Cytokines and Vitamin D in Probable Alzheimer#cod#x00027;s Disease with Depression Anindita Banerjee 1, 2 ;Vineet Kumar Khemka.
Guangxian Zhao 1, # ;Xian W
Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Evaluation of Hyperbaric Oxygen Treatment in Acute Traumatic Spinal Cord Injury in Rats Using Diffusion Tensor Imaging Sun Wenzhi 1 ;Li Zhuo 2 ;Lu Shibao.
Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua.
Minwen Xu 1 ;Olga Sizova 3 ;Liefeng Wang 2, 3 ;Dong-Ming Su 3 ;
Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer#cod#x02019;s.
CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain Zhang Lin-Yuan 1 ;Lin #cod#x0002A;Pan 2 ;Pan Jiaji 3 ;Ma.
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice Liu Huaqin 1, 2 ;Yu Zhui 1, 3 ;Li Ying 1, 4 ;Xu Bin 1, 5 ;Yan Baihui.
Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP Liu Xiangrong 1, 2, 3 ;Wen Shaohong 1, 2,
Peng Fangyu 1, 2 ;Xie Fang 1 ;Muzik Otto 3, 4 ;
Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells Qianfa Long 1,
Galanin Protects from Caspase-8/12-initiated Neuronal Apoptosis in the Ischemic Mouse Brain via GalR1 Li Yun;Mei Zhu;Liu Shuiqiao;Wang Tong;Li Hui;Li Xiao-Xiao;Han.
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Mengfei Cai 1 ;Wenting.
Deyong Lv 1, 2, 3 ;Jingbo Li 4 ;Hongfu Li 3 ;Yu Fu 5 ;Wei Wang 1, 2 ;
Fig. 2. Expression of Ninj1 in cortices of ischemic hemispheres of rat brains at 1 day post-MCAO. Coronal brain sections were prepared at 1 day post-MCAO.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Cai Mengfei 1 ;Zhang Wenting.
Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua.
Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage Guofen Gao 1 ;Nan Zhang 1 ;Yue-Qi Wang 1 ;Qiong Wu 1 ;Peng Yu 1 ;Zhen-Hua.
Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology Lu Jiao 1, 2 ;Duan Xuefeng 1 ;Zhao Wenming 1 ;Wang.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Promoting Neurovascular Recovery in Aged Mice after Ischemic Stroke - Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Mengfei Cai 1 ;Wenting.
Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells Qianfa Long 1,
Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells Qianfa Long 1,
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Chen Yali;Yin Mengmei;Cao Xuejin;Hu Gang;Xiao Ming;
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Pkc#cod#x003B4; Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products.
Wei Zuo 1 ;Feng Yan 2, 3 ;Bo Zhang 1 ;Jiantao Li 1 ;Dan Mei 1 ;
Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer#cod#x02019;s Disease and Related Tauopathies Diana L Castillo-Carranza 1, 2 ;Ashley N.
CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain Zhang Lin-Yuan 1 ;Lin #cod#x0002A;Pan 2 ;Pan Jiaji 3 ;Ma.
LMNA -mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy Sui Tingting 1 ;Liu Di 1 ;Liu Tingjun 1 ;Deng.
Lack of Evidence for Activation of the Hedgehog Pathway in Psoriasis
Volume 12, Issue 1, Pages (July 2015)
Volume 19, Issue 8, Pages (August 2012)
Supplementary Figure 1 A B C SW620 HT29 SW620
Ctip2 directly regulates Notch1 expression in differentiated cells.
Schematic demonstration of hedgehog signal pathway.
Presentation transcript:

Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy Saidan Ding 1 ;Jianjing Yang 2 ;Xueli Huang 3 ;Leping Liu 1 ;Jiangnan Hu 4 ;Zhu Xu 2 ;Qichuan Zhuge 2 ; 1 Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research, Department of Surgery Laboratory, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang 325000, China ; 2 Department of Neurosurgery, the First Affiliated Hospital, Wenzhou Medical University, Zhejiang 325000, China ; 3 School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang 325000, China ; 4 Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA ; Figure 3. The Shh pathway was inactivated in MHE by DA burden A and B Cortical homogenates from control and MHE rats were subjected to immunoblotting with antibodies against Shh, Ptch, Smo, Gli1, Gli2 and #cod#x003B2;-actin and subsequent densitometry B . C-G Free floating coronal sections from cortexes of control or MHE rats were immunostained for Shh C Ptch D Smo E Gli1 F Gli2 G red, GFAP green. Scale bar, 25 #cod#x003BC;m. MRGD, merged image. H and I Cortical homogenates from control, 1 #cod#x003BC;g or 10 #cod#x003BC;g DA- injected i.c.v rats were subjected to immunoblotting with antibodies against Shh, Ptch, Smo, Gli1, Gli2 and #cod#x003B2;-actin, and subsequent densitometry I . J-N Free floating coronal sections from cortexes of control or 10 #cod#x003BC;g DA-injected i.c.v rats were immunostained for Shh J Ptch K Smo I Gli1 M Gli2 N red, GFAP green. Scale bar, 25 #cod#x003BC;m. MRGD, merged image. O and P Cells were treated with different doses of DA for 24 hrs before being subjected to immunoblotting with antibodies against Shh, Ptch, Smo, Gli1, Gli2 and #cod#x003B2;-actin, and subsequent densitometry P . Q-U Cells were treated with different doses of DA for 24 hrs and immunostained for Shh Q Ptch R Smo S Gli1 T Gli2 U red, GFAP green. Scale bar, 50 #cod#x003BC;m. MRGD, merged image. Data were shown as mean #cod#x000B1; SD. #cod#x0002A; p #cod#x0003C;0.05, #cod#x0002A;#cod#x0002A; p #cod#x0003C;0.01 vs controls. Aging and Disease,null,8(4),442-457. Doi:10.14336/AD.2016.1123