Volume 139, Issue 1, Pages 190-193 (January 2011) Beneficial Effects of Treatment With Anti-IgE Antibodies (Omalizumab) in a Patient With Severe Asthma and Negative Skin-Prick Test Results  Dr Maarten van den Berge, MD, PhD, Dr Ronald G. Pauw, MD, Dr Jan G.R. de Monchy, MD, PhD, Dr Cees A. van Minnen, MD, Dr Dirkje S. Postma, MD, PhD, Dr Huib A.M. Kerstjens, MD, PhD  CHEST  Volume 139, Issue 1, Pages 190-193 (January 2011) DOI: 10.1378/chest.10-0128 Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 1 Chest radiograph at time of first exacerbation. CHEST 2011 139, 190-193DOI: (10.1378/chest.10-0128) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 2 A bronchial biopsy specimen showing a thickened basement membrane and diffuse tissue eosinophilia (arrows) compatible with asthma. CHEST 2011 139, 190-193DOI: (10.1378/chest.10-0128) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 3 All FEV1 measurements carried out between 2000 and 2009. The FEV1 improved and remained stable after the start of omalizumab in December 2006. After withdrawal of omalizumab, FEV1 deteriorated. Finally, FEV1 improved again when omalizumab was restarted. CHEST 2011 139, 190-193DOI: (10.1378/chest.10-0128) Copyright © 2011 The American College of Chest Physicians Terms and Conditions