DUAL FUNCTIONAL NANOPARTICLES FOR M1 ACETYLCHOLINE RECEPTOR SELECTIVE ALLOSTERIC POTENTIATOR TO TARGET AMYLOID PLAQUES IN THE BRAIN OF STREPTOZOTOCIN-INDUCED ALZHEIMER'S DISEASE  Rizwan Basha Khatwal, Malay K. Samanta, Jayasankar Kosaraju, Anil Dubala, Chinni Santhi Vardhan, Manjunatha Narayanappa, Afzal Azam, M.N. Satish Kumar  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 10, Issue 4, Pages P781-P782 (July 2014) DOI: 10.1016/j.jalz.2014.05.1508 Copyright © 2014 Terms and Conditions

Fig 1 (a) Treatment with BQCA and BQCA loaded NPs in STZ induced rats reverses the reference and working memory deficits in Radial Arm Maze task. Data expressed as mean ± SD (n=10). Significance was determined by two-way ANOVA followed by Bonferroni post-test. ###P < 0.001, ##P < 0.01 vs sham control, ***P < 0.001, **P < 0.01, *P < 0.05 vs negative control were considered significant. (A) Reference memory errors, (B) correct working memory errors and (C) incorrect working memory errors. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014 10, P781-P782DOI: (10.1016/j.jalz.2014.05.1508) Copyright © 2014 Terms and Conditions

Fig 1 (b) Treatment with BQCA and BQCA loaded NPs in STZ induced rats reverses the spatial learning deficits in HB task. Data expressed as mean ± SD (n =10). Significance was determined by two-way ANOVA followed by Bonferroni post-test. ###P < 0.001, ##P < 0.01 vs sham control, ***P < 0.001, **P < 0.01, *P < 0.05 vs negative control were considered significant. (A) Number of hits, (B) number of errors and (C) trial completion time. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014 10, P781-P782DOI: (10.1016/j.jalz.2014.05.1508) Copyright © 2014 Terms and Conditions