From: Treatment of Postmenopausal Osteoporosis with Slow-Release Sodium Fluoride: Final Report of a Randomized Controlled Trial Ann Intern Med. 1995;123(6):401-408.

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From: Treatment of Postmenopausal Osteoporosis with Slow-Release Sodium Fluoride: Final Report of a Randomized Controlled Trial Ann Intern Med. 1995;123(6):401-408. doi:10.7326/0003-4819-123-6-199509150-00001 Figure Legend: Dependence of individual vertebral fracture rate (IVFR) on baseline L2-L4 bone density (BD) in the groups receiving slow-release sodium fluoride (SR-NaF) and placebo.Top.Bottom.All patients had radiologic evidence of osteopenia. However, six patients (three in each group) had baseline L2-L4 bone density greater than 95% that of a normal 30-year-old woman (mean). Values were probably falsely high because of severe scoliosis in three patients and compression fracture in one patient (which yielded a subnormal vertebral area) and reactive degenerative arthritis and aortic calcification, respectively, in two patients (which added extraskeletal mass). Dependence of individual vertebral fracture rate on baseline L2-L4 bone density in the group receiving sodium fluoride. Dependence of individual vertebral fracture rate on baseline L2-L4 bone density in the group receiving placebo. Date of download: 3/3/2018 Copyright © American College of Physicians. All rights reserved.

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