Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Mike Lin
NSAIDs Therapeutic Effects List of NSAIDs Anatomic Pathway Mechanism Aspirin & Ibuprofen Side Effects
Therapeutic Effects Analgesic: Reduction of pain perception Antipyretic: Reduction in fever Anti-Inflammatory: Reduction of inflammation/swelling
List of NSAIDs
Anatomic Pathway Damaged tissue causes the release of Prostaglandins from Cyclooxygenase Enzymes: Prostaglandins Lipid compounds that have a hormone-like effect Stimulate nerve endings to send pain signals to the brain via the CNS Cyclooxygenase Enzyme (COX): COX1 - Maintenance of gastrointestinal tract and blood platelets COX2 - Related to inflammation and pain responses
Mechanism NSAIDs inhibit COX enzymes: Aspirin irreversibly modifies COX enzymes to no longer function Ibuprofen competitively blocks substrate binding sites on enzymes Aspirin Ibuprofen
Aspirin
Ibuprofen
Side Effects Blood thinning due to lack of blood clotting Stomach ulcers from degradation of stomach lining Kidney failure from prolonged use
Summary NSAIDs - Nonsteroidal Anti-Inflammatory Drugs Reduce PAIN, FEVER, and INFLAMMATION Function by inhibiting COX Enzymes from producing Prostaglandins Chronic overuse can lead to serious health issues and damage