Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Slides:



Advertisements
Similar presentations
D3-Analgesics By Caroline Bexfield and Juan David Posada.
Advertisements

Medicines and drugs Analgesics.
Anti-inflammatory Drugs # Lab 4 #. Inflammation: it is a biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells,
Synthesis, functions and
Nonsteroidal Anti- inflammatory Drugs ผศ. พญ. มาลียา มโนรถ.
FEVER The hypothalamus is the organ responsible for temperature regulation. It contains thermosensitive neurons to control thermoregulatory functions in.
ANAESTHESIA AND ANTICOAGULANTS
Prostaglandins and Related Compounds 1Dr. Nikhat Siddiqi.
Pharmacology-1 PHL 211 2nd Term 3rd Lecture By Abdelkader Ashour, Ph.D. Phone:
MEDICINAL CHEMISTRY- III introduction Wed. 2/ 5/ 1432H Prof. Dr. Wafaa Zaghary PHC 426.
Non-steroidal Anti- Inflammatory Drugs And Their Effect on Renal Function.
Non-steroidal anti-inflammatory drugs
Chapter 12 Anti-inflammatory Agents. Copyright 2007 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved Nonsteroidal.
CLINICAL CASES Chen,Chun-Huang(Alex). Case NO.5 An elderly woman with arthritis becomes confused about her medications, and start taking 20 aspirin tablet.
UW Biology of Addiction Unit V: Depressants
N ON - STEROIDAL ANTI - INFLAMMATORY DRUGS. OBJECTIVES At the end of the lecture the students should : Define NSAIDs Describe the classification of this.
How do different analgesics prevent pain?. What is pain? pain |pān|noun physical suffering or discomfort caused by illness or injury : she's in great.
Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. Chapter 6 Nonopiod (Nonnarcotic) Analgesics.
Copyright © 2008 Lippincott Williams & Wilkins. Introductory Clinical Pharmacology Chapter 18 Nonopioid Analgesics: Nonsteroidal Anti-Inflammatory Drugs.
Medicines and drugs Analgesics.
Pain Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage.
Chapter 10: Non-narcotic Anti-Inflammatory Analgesics Presented by: Katie and Steffani.
NSAIDS – Aspirin, Ibuprofen, Celebrex and Beyond.
CHAPTER © 2012 The McGraw-Hill Companies, Inc. All rights reserved. 20 Nonopioid Analgesics, Nonsteroidal Antiinflammatories, and Antigout Drugs.
Michelle Fisher. Ibuprofen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases.
CHEMISTRY 4000 Problem Set #1: Rofecoxib (aka Vioxx ® ) Fall 2012 Dr. Susan Findlay.
Some naturally occurring fatty acids in animals
Treatment of Inflammation Antihistamines Aspirin NSAIDS Glucocorticoids Others –Gold compounds –Antimalarial agents –Immunodulating agents.
COO - CH 2 COO - CH 2 C COO - O AcCoA COO - CH 2 OC HCOO - CH 2 CH 3 C-SCoA O COO - CH 2 C COO - O CH 2 HC COO - OH COO - CH 3 C O CO2CO2 COO - CH 2 C.
Medicines and drugs Analgesics.
D.3.2 Describe the use of derivatives of salicylic acid as mild analgesics and compare the advantages and disadvantages of using aspirin and paracetamol.
NSAIDs.
Preparation and Examination of Aspirin
- nonsteroidal anti-inflammatory drugs (NSAIDs), are used to combat inflammation. - Their antiinflammatory action equals that of aspirin. - have analgesic.
Generic Voltarol: An Effective Pain Reducing Medicine.
Pick up the colored cards on the cabinet: Ms. Joachim Pathophysiology.
Experiment 1 – Graded Dose-Response Curve
Non-steroidal anti-inflammatory drugs
PAIN MANAGEMENT IN DENTISTRY 1. 2  Pain is defined as an unpleasant sensation that can be either acute or chronic and that is a consequence of complex.
Eicosanoids. Deficiency symptoms in the absence of essential fatty acids from the diet: Nonlipid diet plus vitamins A and D Rat ––––––––––––––––––––––––––––––––
ANALGESIC DRUGS # PHL 322, Lab. 3#.
evalution OF ANALGESIC AGENTS
NONSTEROIDAL ANTIINFLAMATORY DRUGS(NSAIDS)
Anti-inflammatory Drugs
Eicosanoids.
Chapter 71 Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs and Acetaminophen 1.
Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs and Acetaminophen 1.
Prostaglandins and Related Compounds
Inflammation lecture 4 Dr Heyam Awad FRCPath.
“Traditional NSAIDs” versus “COXIBs”
Kaylee, Rachel, Erin, Hailey, Anna
Prostaglandin, Leukotriene, and Thromboxane Synthesis
Medicines and drugs Analgesics.
Eicosanoid Synthesis Molecular Biochemistry II
Non STEROIDAL Anti-inflammatory Drugs
Non-narcotic Analgesics
Metabolic Pathways A metabolic pathway begins with a specific molecule and ends with a product Each step is catalyzed by a specific enzyme- importance.
Medicines and drugs Analgesics.
Arachidonate Metabolism
Evaluation of the anti-inflammatory activity of NSAIDs and glucocorticoids Dr. Raz Mohammed
Non-narcotic Analgesics
Evaluation of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Lab 4)
Enzyme Inhibition Examples
ACUTE PAIN MANAGEMENT FOR EMS
Evaluation of the anti-inflammatory activity of NSAIDs and glucocorticoids Dr. Raz Mohammed Lab
Terms and Definitions Analgesics:
pain management Lecture headlines :
Drugs for Muscles and Joint Disease and Pain
Non opioids pain management
Presentation transcript:

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Mike Lin

NSAIDs Therapeutic Effects List of NSAIDs Anatomic Pathway Mechanism Aspirin & Ibuprofen Side Effects

Therapeutic Effects Analgesic: Reduction of pain perception Antipyretic: Reduction in fever Anti-Inflammatory: Reduction of inflammation/swelling

List of NSAIDs

Anatomic Pathway Damaged tissue causes the release of Prostaglandins from Cyclooxygenase Enzymes: Prostaglandins Lipid compounds that have a hormone-like effect Stimulate nerve endings to send pain signals to the brain via the CNS Cyclooxygenase Enzyme (COX): COX1 - Maintenance of gastrointestinal tract and blood platelets COX2 - Related to inflammation and pain responses

Mechanism NSAIDs inhibit COX enzymes: Aspirin irreversibly modifies COX enzymes to no longer function Ibuprofen competitively blocks substrate binding sites on enzymes Aspirin Ibuprofen

Aspirin

Ibuprofen

Side Effects Blood thinning due to lack of blood clotting Stomach ulcers from degradation of stomach lining Kidney failure from prolonged use

Summary NSAIDs - Nonsteroidal Anti-Inflammatory Drugs Reduce PAIN, FEVER, and INFLAMMATION Function by inhibiting COX Enzymes from producing Prostaglandins Chronic overuse can lead to serious health issues and damage