Professor Chris Whitty CB FMedSci Chief Scientific Adviser The future of the NIHR NIHR: 10 years of delivering health and care research for the nation QEII Centre, London Wednesday 18 May 2016 Professor Chris Whitty CB FMedSci Chief Scientific Adviser Department of Health

Building on 10 remarkable years The extraordinary advances in health are based on evidence and science, properly applied. Most health interventions depend on science from multiple disciplines from the most basic to the most applied. Future advances need to take account of changing need, new threats, new scientific opportunities.

Age-standardised mortality rates England and Wales (ONS 2014)

Ten leading causes of death in females, 2003-2013, England & Wales (ONS)

Must take account of distribution of need Must take account of distribution of need. Dementia in women (L), heart disease (R)

Population 85 and over: 1992, 2015, 2033 (ONS).

Spend by UK public funder Basic research Applied research Basic research Applied research Data taken from NIHR Dashboard for Financial Year 2013-14 and does not include the PRP and several new NIHR funding initiatives (eg. HPRUs) that started in 2014. The update of the UKCRC report for Calendar Year 2014 is currently in preparation and will be available in shortly. This will include the entire DH R&D spend. MRC NIHR Research spend 2013/2014

NIHR-Supported Facilities Newcastle Leeds Leicester Peninsula Bradford Manchester Sheffield Liverpool Nottingham Birmingham Oxford Cambridge London Bristol Brighton Southampton Exeter NIHR Biomedical Research Units NIHR Health Protection Research Units NIHR Biomedical Research Centres NIHR Blood and Transplant Research Units NIHR Healthcare Technology Co- operatives NIHR Diagnostic Evidence Co-operatives NIHR-supported Clinical Research Facilities NIHR School for Public Health Research NIHR School for Primary Care Research NIHR/CR-UK Experimental Cancer Medicine Centres NIHR Surgical Reconstruction and Microbiology Research Centre NIHR Collaborations for Leadership in Applied Health Research and Care NIHR Biomedical Research Units Newcastle – dementia Leeds – musculoskeletal Central Manchester – musculoskeletal Liverpool – gastrointestinal Nottingham – hearing/respiratory/gastrointestinal Leicester – cardiovascular/respiratory/nutrition Birmingham – gastrointestinal Bristol – cardiovascular/nutrition Oxford – musculoskeletal Southampton – respiratory London Imperial – cardiovascular/respiratory Barts – cardiovascular UCL – dementia South London and Maudsley - dementia NIHR Health Protection Research Units University College London - Blood Borne and Sexually Transmitted Infections University of Newcastle upon Tyne - Chemical and Radiation Threats and Hazards King’s College London - Emergency Preparedness and Response University of Liverpool - Emerging and Zoonotic Infections London School of Hygiene and Tropical Medicine - Environmental Change and Health University of Liverpool - Gastrointestinal Infections King’s College London - Health Impact of Environmental Hazards Imperial College London - Healthcare Associated Infections and Antimicrobial Resistance University of Oxford - Healthcare Associated Infections and Antimicrobial Resistance London School of Hygiene and Tropical Medicine - Immunisation Imperial College London - Respiratory Infections University of Bristol - Evaluation of Interventions Imperial College London - Modelling Methodology NIHR Biomedical Research Centres Newcastle Oxford Cambridge Southampton Imperial UCLH Great Ormond St Moorfields Guy’s and St Thomas Royal Marsden South London and Maudsley NIHR Blood and Transplant Research Units University of Bristol – New Red Blood Cell Products University of Cambridge – Donor Health and Genomics University of Cambridge – Organ Donation and Transplantation University College London – Stem Cells and Immunotherapies NIHR Healthcare Technology Co-operatives Birmingham Bradford Leeds Nottingham Sheffield Barts Guy’s & St Thomas’ NIHR/CR-UK Experimental Cancer Medicine Centres Leicester Barts/ Brighton ICR King’s College London UCL Manchester NIHR Diagnostic Evidence Co-operatives NIHR-supported Clinical Research Facilities Alder Hey Brighton and Sussex The Christie Exeter Maudsley Oxford cognitive health South Manchester respiratory and allergy NIHR School for Public Health Research University of Sheffield – Lead Partner University of Cambridge University of Liverpool / Lancaster NE consortium FUSE London School of Hygiene and Tropical Medicine University College London University of Bristol University of Exeter NIHR School for Primary Care Research University of Oxford – Lead Partner University of Manchester Keele University University of Nottingham University of Southampton University of Newcastle-Upon-Tyne NIHR Collaborations for Leadership in Applied Health Research and Care East of England East Midlands Greater Manchester North Thames North West Coast North West London South London South West Peninsula West West Midlands Wessex Yorkshire and Humber NIHR Surgical Reconstruction and Microbiology Research Centre

NIHR Clinical Research Network 15 Local Clinical Research Networks (LCRNs) . Boundaries align with AHSNs. Essential for the testing of new interventions for the NHS in areas of clinical need. Also important for industry and charities.

The future of the future: training Research training has to be appropriate for when trainees become independent scientists. Need to adapt to current pressures on clinical and non-clinical scientists. Need to address the falloff in women in science at postdoctoral level.

Many fields rapidly progressing driven by new and old sciences, supported by NIHR. This will continue over the next 10 years. Stroke mortality