Volume 144, Issue 6, Pages (December 2013)

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A) Chest computed tomography image showing left upper lobe cavitary lesion consistent with invasive pulmonary aspergillosis (IPA) in an allogeneic haematopoietic.

Presentation transcript:

Volume 144, Issue 6, Pages 1913-1922 (December 2013) An Update on Pulmonary Complications of Hematopoietic Stem Cell Transplantation Amy K. Chi, MD, Ayman O. Soubani, MD, FCCP, Alexander C. White, MD, FCCP, Kenneth B. Miller, MD CHEST Volume 144, Issue 6, Pages 1913-1922 (December 2013) DOI: 10.1378/chest.12-1708 Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 1 The timeline of pulmonary complications following hematopoietic stem cell transplantation (HSCT). BO = bronchiolitis obliterans; CHF = congestive heart failure; CMV = cytomegalovirus; COP = cryptogenic-organizing pneumonia; DAH = diffuse alveolar hemorrhage; ES = engraftment syndrome; GVHD = graft-vs-host disease; HSV = herpes simplex virus; HZV = herpes zoster virus; IPS = idiopathic pneumonia syndrome; PTLPD = posttransplant lymphoproliferative disorder; RSV = respiratory syncytial virus; VOD = venoocclusive disease. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 2 Chest CT image showing a left upper lobe cavitary lesion in a patient with invasive pulmonary aspergillosis following allogeneic HSCT. See Figure 1 legend for expansion of abbreviation. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 3 Chest CT image showing bilateral areas of consolidation in a patient with DAH. See Figure 1 legend for expansion of abbreviation. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 4 High-resolution CT image showing mosaic pattern in a patient with BO. See Figure 1 legend for expansion of abbreviation. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 5 BO pathology showing intraluminal polypoid plug of granulation tissue found within the terminal and respiratory bronchioles (*) (hematoxylin and eosin (HE) stain; magnification × 200). See Figure 1 legend for expansion of abbreviation. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 6 COP pathology showing intraluminal buds of granulation tissue in small airways and alveolar ducts (*) with associated chronic inflammation in the surrounding alveoli (hematoxylin and eosin (HE) stain; magnification × 100). See Figure 1 and 5 legends for expansion of abbreviations. CHEST 2013 144, 1913-1922DOI: (10.1378/chest.12-1708) Copyright © 2013 The American College of Chest Physicians Terms and Conditions