B. Bai, Y. Li Osteoarthritis and Cartilage

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Danshen prevents articular cartilage degeneration via antioxidation in rabbits with osteoarthritis B. Bai, Y. Li Osteoarthritis and Cartilage Volume 24, Issue 3, Pages 514-520 (March 2016) DOI: 10.1016/j.joca.2015.10.004 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Histomorphological sections stained with HE staining (magnification: 10×10) and illustrating articular cartilage lesions. A (control group): Normal articular cartilage with intact surface. B (OA group): The cartilage matrix demonstrated loss of straining and proliferative chondrocyte clusters in the superficial and middle zones. C (Danshen OA group): Unsmooth surface. The cartilage cells in the superficial zone appear disorganized. Osteoarthritis and Cartilage 2016 24, 514-520DOI: (10.1016/j.joca.2015.10.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Comparison of grade for the toluidine blue staining loss of the cartilage matrix between the experimental groups.*P < 0.001 compared to control group; #P < 0.017 compared to OA group. Osteoarthritis and Cartilage 2016 24, 514-520DOI: (10.1016/j.joca.2015.10.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Comparison of grade, stage, and scores for articular cartilage histopathology between the experimental groups. (A) The grade evaluation of articular cartilage histopathology. (B) The stage evaluation of articular cartilage histopathology. (C) The score evaluation of articular cartilage histopathology. *P < 0.001 compared to control group; #P < 0.017 compared to OA group. Osteoarthritis and Cartilage 2016 24, 514-520DOI: (10.1016/j.joca.2015.10.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 A comparison of the GSH concentration levels in the synovium and articular cartilage tissues between the control, OA, and Danshen OA groups, respectively (mean ± 95% CI, n = 8).*P < 0.001 compared to control group; #P < 0.001 compared to OA group. Osteoarthritis and Cartilage 2016 24, 514-520DOI: (10.1016/j.joca.2015.10.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 A comparison of the MDA concentration levels in the synovium and articular cartilage tissues between control, OA, and Danshen OA groups (mean ± 95% CI, n = 8).*P < 0.001 compared to control group; #P < 0.001 compared to OA group. Osteoarthritis and Cartilage 2016 24, 514-520DOI: (10.1016/j.joca.2015.10.004) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions