Med Chem Tutoring for AEDs By Alaina Darby
Which of the following R” groups would be suitable for partial seizures? Methyl Ethyl Benzene Propyl C
Which of the following is not a prodrug? B A Mephobarbital… must demethylate C Primidone… must add oxygen
Decreases sodium influx into excitable tissues Membrane-stabilization Which of the following would not true of hydantoins mechanism of action? Decreases sodium influx into excitable tissues Membrane-stabilization Decrease in membrane permeability to Ca2+ Decrease of excitatory NT from postsynaptic vesicles C
Why is phenytoin not recommended for preschool aged children? Gingival hyperplasia Osteomalacia Megoblastic anemia Sedation A
Why would fosphenytoin be considered over phenytoin? Concerns with gingival hyperplasia Need to administer with a basic drug Need to administer with an acidic drug Need to use for absence seizures B
Which of the following is not a side effect of phenytoin? SJS TEN Teratogenicity Sedation D
Which of the following can be used for absence seizures? Ethosuximide Methsuximide Phenytoin Phenobarbital A
Which of the following is the benzodiazepine that can be formulated most easily as an injectable? Lorazepam Midazolam Diazepam Clonazepate B (the imidazole is much more basic so it can form a salt)
Which of the following is a prodrug? Lorazepam Midazolam Diazepam Clonazepate D
Which of the following causes the most hepatotoxicity? Phenytoin Phenobarbital Valproic Acid Carbamazapine C
Which of the following does not cause a rash due to its reactive metabolites? Phenytoin Ethosuximide Valproate Carbamazapine B
Which of these does not form an epoxide metabolite? Phenytoin Ethosuximide Valproate Carbamazapine B
Which of the following would not be contraindicated if a patient is allergic to TMP-SMX? Acetazolamide Gabapentin Zonisamide Topiramate B
Which of the following can cause kidney stones? Acetazolamide Gabapentin Zonisamide Topiramate D
Which of the following can undergo benzylic hydroxylation? Acetazolamide Gabapentin Pregabalin Tigabine D
Which of the following may effect CYPs? Zonisamide Gabapentin Levetiracetam Tigabine A
Which of the following does not induce CYP3A4? Rufinamide Valproate Phenobarbital Phenytoin B