Efficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin: A statistical approach  Don F. du Toit, Benjamin Longo-Mbenza,

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Presentation transcript:

Efficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin: A statistical approach  Don F. du Toit, Benjamin Longo-Mbenza, Benedict J. Page, Venant Tchokonte-Nana  International Journal of Diabetes Mellitus  Volume 3, Issue 1, Pages 57-64 (May 2015) DOI: 10.1016/j.ijdm.2011.01.007 Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 1 The pancreas of the laboratory rat is prised away to expose the point of ligation (double bold line) in the splenic lobe. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 2a Dual expression index insulin in blue and caspase3 in green across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 2b Efficiency levels of insulin and caspase3 gene co-expression across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 2c Dual expression index of insulin in blue and Pdx1 in green across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 2d Efficiency levels of insulin and Pdx1 co-expression across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 3a Dual expression index of insulin in blue and Ngn3 in green across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 3b Efficiency levels of insulin and Ngn3 co-expression across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 3c Dual expression index of insulin in blue and NeuroD in green across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 3d Efficiency levels of insulin and NeuroD across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 4a Dual expression index of insulin in blue and Pax6 in green across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions

Figure 4b Efficiency levels of insulin and pax6 co-expression across the period of times pre- and post-PDL. International Journal of Diabetes Mellitus 2015 3, 57-64DOI: (10.1016/j.ijdm.2011.01.007) Copyright © 2011 International Journal of Diabetes Mellitus Terms and Conditions