Supplementary figure S1

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Supplementary figure S1 YPD MG 200 ng ml-1 + Mg 200µM + Mn 200µM Supplementary figure S1 serial dilution assays to show drug susceptibility of C. albicans to MG (200 ng ml-1) and supplementation with either 200μM Mg or 200μM Mn

Supplementary figure S2

Supplementary figure S2 MG susceptibility screening of 240 TF Mutants were determined at 300 ng ml-1 by serial dilution assay, only repeatedly sensitive strains were picked up for further analysis.

(nmol per mg dry lipid wt.) (% of normalized PGL mass spectral signal) Supplementary figure S3 (nmol per mg dry lipid wt.) PG L amount (% of normalized PGL mass spectral signal) PGL composition

Figure S3 Sterols and phosphoglycerides (PGLs) composition under MG treatment as compared with untreated cells. The amount of sterols are represented as % of normalized total sterol mass spectral signal and PGL amount is represented as % of normalized PGL mass spectral signal. Values are means ± SD of 5 independent experiments (n=3). PC: Phosphatidyl choline; PE: Phosphatidyl ethanolamine; PI: Phosphatidyl inositol; PS: Phosphatidyl serine; PG: Phosphatidyl glycerol; PA: Phosphatidic acid;Lyso PC: Phosphatidyl choline; Lyso PE: Phosphatidyl ethanolamine; Lyso PG: Phosphatidyl glycerol

Supplementary figure S4 stp2Δ upc2Δ Supplementary figure S4 UPC2 and STP2 have common target, RT-PCR showing log2 ratios of MET6 in stp2Δ and upc2Δ as compared to their respective wild-type strains.