Imunoglobulins – structure and function Production of immunoglobulins

Slides:

Advertisements

Similar presentations

Humoral Immunity Ajith Sominanda Department of Anatomy.

Advertisements

Chapter15 B cell mediated immune response. B cells mediated immune response Humoral immunity(HI) or antibody mediated immunity: The total immunological.

TODAY B CELL DEVELOPMENT.

Immunoglobulins, immune response Martin Liška. 1. The structure of immunoglobulins.

Adaptive immunity How can the immune system recognize so many different (previously unseen) insults? How does the immune system learn? How do B cells produce.

Antibodies: Structure And Function

Humoral Immunity and Complement Robert Beatty MCB150.

Adaptive immunity How can the immune system recognize so many different (previously unseen) insults? How does the immune system learn? How do B cells produce.

Ab formation. Hallmarks of the Immune Response Self/Non-self Discrimination Memory Specificity.

General Microbiology (Micr300)

ANTIBODY STRUCTURE AND FUNCTION

Antibodies and T Cell Receptor Genetics 2011

Lecture 2 Antigens, Receptors and Immunoglobulins.

Immunoglobulins structure and function

IMMUNOGLOBULINS STRUCTURE AND FUNCTION

B CELL Public Health MSc 6th week, DEFINITIONS Antigen (Ag) - any substance, which is recognized by the mature immune system of a given organism.

Adaptive Immunity  Response occurs within days of the infection  Highly specific  Highly diverse  Memory component  Major cell types involved: T cells,

Microarray analysis indicates that different subsets of B cells express specific “gene signatures.”

Immunity Innate and Adaptive Immunity Cells of the Immune System

Antibodies and antigens Antibodies = immunoglobulins Antibodies bind antigens.

Humoral Immunity Antibodies.

Komal Choudhary Lecturer School of Biotechnology DAVV Indore.

H. HogenEsch, 2005 Antibody structure and function Parham – Chapter 2.

Humoral Immunity presented by Dr. MAHROO MIRAHMADIAN Professor of Immunology Tehran University of Medical Sciences.

Chapter 17: Adaptive Immunity: Specific Defenses of the Host

Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory.

Chapter 15 B cell mediated immune response. B Cells Lymphocytes that react directly with antigens Require stimulation from Helper T Cells Offspring become.

IMMUNOGLOBULINS STRUCTURE AND FUNCTION Arpad Lanyi

Heavy Chains – Isotypic Differences

B Cell Activation and Antibody Production Lecture 15.

Ch4. Antibody Structure and the Generation of B-cell diversity.

Immunoglobulins - structure. Immunoglobulins - function. Genetic background of immunoglobulin production. Biological and chemical characteristics of immunoglobulin.

MUDr. Martina Vachová Topics: 31. Immunoglobulins - structure. 32. Immunoglobulins - function. 33. Genetic background of immunoglobulin production.

Immunoglobulins, immune response

8 th lecture The collaborations between innate and adaptive immunity. Antibody types and functions.

Lector Tvorko M. S.. ANTIBODIES (IMMUNOGLOBULINS) Antibodies are globulin proteins (immunoglobulins) that react specifically with the antigen that stimulated.

COLLABORATION OF INNATE AND ADAPTIVE IMMUNITY ANTIBODY STRUCTURE AND FUNCTION 8 th week Physiotherapy BSc 2015.

Immune system Haixu Tang School of Informatics. Human lymphoid organs.

B CELLS. Innate immunity Adaptive immunity T cells B cells Intracellular pathogens Extracellular pathogens Recognition Communication Elimination Recognition.

ANTIBODIES Agents of Immunity - A Guide for Teachers - Prepared by Johanna Mancini for Immunology Montreal August 2008.

ANTIBODIES. Cells cooperation in immune response.

Antigens Immunogen – a molecule that specifically interacts with an antibody or lymphocyte and elicits an immune response Antigenic determinants (epitopes)

Antibody-mediated Immunity Dr. Hend Alotaibi Assistant Professor & Consultant College of Medicine, King Saud University Dermatology Department /KKUH.

Humoral immunity Antibody structure Antibody diversity

Adaptive Immunity Central objective: Protect against foreign invaders memoryCreate memory of invasion to prevent recurrent infection specificResponse.

Antibody Diversity. Immunoglobulin: antibody Antibody response: B cells, with the help of T cells, produce antibody to antigen, preserve the ability to.

Humoral Immune response

Antibodies: Structure And Function

Chapter 43 The Immune System.

B Cells and Antibodies Abul K. Abbas UCSF FOCiS.

The Adaptive Immune Response

Immunology Ch Microbiology.

Effector mechanisms of humoral immunity

ADAPTIVE IMMUNE RESPONSE

Objectives; Define secretary IgA Describe structure & functions of IgM Compare the antigenic receptor of B lymphocyte Assess the role of IgE.

Antibodies (Immunoglobulins)

CELL-MEDIATED IMMUNITY

MUDr. Martina Vachová Topics: 31

HKMU Faculty of Medicine

Resistance and the Immune System: Adaptive Immunity

Antibodies: Structure And Function

Chapter 13 Effector Responses

The clonal selection model of immunogenesis

Effector Mechanisms of Humoral Immunity

What class of antibody exists as a pentamer?

Humoral Immunity.

Introduction to Microbiology

Presentation transcript:

Imunoglobulins – structure and function Production of immunoglobulins Imunoglobulins – structure and function Production of immunoglobulins Genetic determination of immunoglobulin production Clonal selection theory

Antigen and epitope

Molecule of IgG

Hypervaribale region of immunoglobulin molecule binds epitope of the antigen

Variable region of immunoglobulin molecule

VDJ Recombination Germline configuration D to J recombination V segments D segments J segments Constant region exons D to J recombination V to DJ recombination transcription, splicing AAA Issembly Adapted from Janeway 2001

Isotype switching

Isotype switching

Clonal selection theory F.M. Burnet, 1957 During (mainly fetal) development immunocompetent cells of the immune system develop. Each sell is characterized by its own antigen specific receptor. Each cell reacts only with one concrete specific antigen. After exposure to autoantigen during fetal life autoreactive clones are eliminated ( „forbidden clones“). If a concrete cell recognizes its specific antigen, it is stimulated, proliferates and forms a clone = clonal selection. After repeated divisions the cell becomes a terminally differentiated cell, that does not proliferate and after some time dies. The cells of the clone that do not differentiate into the terminal stage become a memory cells which will quickly react after the second exposure to the antigen.

Clonal selection theory Memory cells Elimination of autoreactive clones Blood and periperal lymphatic organs expansion antigen death death Effector cells

Activation and differentiation of B-lymphocytes (clonal selection theory in B-lymphocyte development) Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier

Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier

Isotype The class or subclass of an immunoglobulin. Antigenic determinats are on constant part of immunoglobulin molecule.

Idiotype An antigenic determinant on the variable region of a specific antibody.

Interaction idiotype-antiidiotype Epitop Paratop antigen Antiidiotyp idiotyp Antibody Ab 1 Antibody Ab 2 Antibody Ab 3

www.immunology.klimov.tom.ru/1-1.php.

IgG

Primoary and secondary antibody immune response Secondary antibody response Primary antibody response IgM IgG First exporsure Serum antibody titers Weeks Second exposure to antigen

Downloaded from: StudentConsult (on 18 July 2006 11:29 AM) © 2005 Elsevier

IgM on B-cell membrane

Expression of surface immunoglobulins on B-cells

Formation of Secretory IgA Downloaded from: StudentConsult (on 20 July 2006 11:29 AM) © 2005 Elsevier

Affinity: The strength of the binding between a single site of an antibody (one variable region) and an epitope. Avidity: The overall strength of interaction between and antibody and antigen. The avidity depends on affinity and the valency of interactions.

Antibody affinity http://pathmicro.med.sc.edu/mayer/rx-2.jpg

Affinity and avidity IgA IgG IgM

Biological functions of immunoglobulin molecules Activation of complement system (IgG, IgM) Opsonization (particularly IgG) Neutralization of antigens (IgG, IgA, IgM) Adherence interference (IgA, IgG) Antibody dependent cellular cytotoxicity (ADCC) Agglutation, precipitation (IgG, IgM) Mast cells degranulation (IgE) Transport through placenta (IgG) Imunoregulation (mainly IgG)

Antibody dependent cellular cytotoxicity (ADCC) Virus-infected Cell IgG Fab Epitope Fc Fc receptor perforin granzyne NK Cell