Biological aspects of Epstein–Barr virus (EBV)-infected lymphocytes in chronic active EBV infection and associated malignancies Hirokazu Kanegane, Keiko.

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Biological aspects of Epstein–Barr virus (EBV)-infected lymphocytes in chronic active EBV infection and associated malignancies Hirokazu Kanegane, Keiko Nomura, Toshio Miyawaki, Giovanna Tosato Critical Reviews in Oncology / Hematology Volume 44, Issue 3, Pages 239-249 (December 2002) DOI: 10.1016/S1040-8428(02)00115-4

Fig. 1 EBV infection of TCR γ/δ+ T-cells in the peripheral blood from a patient with CAEBV. (panel A) Cytospin preparation of peripheral blood mononuclear cells (original magnification×1000; May–Giemsa stain). Morphologically, most cells are large granular lymphocytes with azurophilic granules in the cytoplasm; (panel B) EBER-1 in situ hybridization of peripheral blood mononuclear cells (original magnification×400). Approximately 50% of mononuclear cells are EBER-1-positive. Critical Reviews in Oncology / Hematology 2002 44, 239-249DOI: (10.1016/S1040-8428(02)00115-4)

Fig. 2 Nodal T-cell lymphoma followed by CAEBV. (panel A) Section of a cervical lymph node from a patient with CAEBV (original magnification×400; H–E stain); (panel B) EBER-1 in situ hybridization of a lymph node shown in panel A (original magnification×400). Most of the cells are EBV-positive. Critical Reviews in Oncology / Hematology 2002 44, 239-249DOI: (10.1016/S1040-8428(02)00115-4)

Fig. 3 Skin lesion in a patient with TCR-γ/δ+ T-cell type CAEBV. (panel A) Massive lymphocytes infiltration of the skin (original magnification×200, H–E stain); (panel B) EBER-1 in situ hybridization shows that most of the cells are EBV-positive (original magnification×200). Critical Reviews in Oncology / Hematology 2002 44, 239-249DOI: (10.1016/S1040-8428(02)00115-4)