Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms Kristiina Malmström, MD, PhD, Anne Pitkäranta, MD, PhD, Olli Carpen,

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Presentation transcript:

Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms Kristiina Malmström, MD, PhD, Anne Pitkäranta, MD, PhD, Olli Carpen, MD, PhD, Anna Pelkonen, MD, PhD, L. Pekka Malmberg, MD, PhD, Markku Turpeinen, MD, PhD, Merja Kajosaari, MD, PhD, Seppo Sarna, MD, PhD, Harry Lindahl, MD, PhD, Tari Haahtela, MD, PhD, Mika J. Mäkelä, MD, PhD Journal of Allergy and Clinical Immunology Volume 118, Issue 3, Pages 591-596 (September 2006) DOI: 10.1016/j.jaci.2006.04.032 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 In situ hybridization for HRV-14 in endobronchial tissue. Left, HRV-14 detected with antisense probe. Hybridization signal is visible as cytoplasmic brown reactivity in respiratory epithelium and in occasional inflammatory cells. The insert shows epithelial cells at higher magnification. A consecutive section from same specimen with HRV-14 sense probe without any hybridization signal. Right, Antisense hybridization of a negative specimen. Bar = 50 μm. Journal of Allergy and Clinical Immunology 2006 118, 591-596DOI: (10.1016/j.jaci.2006.04.032) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 The seasonal distribution of HRV+ endobronchial biopsies detected with ISH. Shaded bars, all biopsies; solid bars, HRV+ biopsies. Journal of Allergy and Clinical Immunology 2006 118, 591-596DOI: (10.1016/j.jaci.2006.04.032) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions