From: Zeb1 Represses Mitf and Regulates Pigment Synthesis, Cell Proliferation, and Epithelial Morphology Invest. Ophthalmol. Vis. Sci.. 2009;50(11):5080-5088.

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From: Zeb1 Represses Mitf and Regulates Pigment Synthesis, Cell Proliferation, and Epithelial Morphology Invest. Ophthalmol. Vis. Sci.. 2009;50(11):5080-5088. doi:10.1167/iovs.08-2911 Figure Legend: Sphere formation reprograms dedifferentiated RPE cells back to a differentiated phenotype. (A, left) A cluster of wild-type RPE cells at day 1 in culture. Middle: wild-type RPE cells after 1 week in culture. Note the appearance of nonpigmented cells with fibroblastic morphology at the edge of the pigmented cells. Right: higher power view of the edge of the pigmented cells after 1 week in culture. (B, left) Wild-type RPE cells at passage 8. Middle: passage 8 RPE cells at day 1 as spheres in suspension culture. Right: feeder layer cells. (C, left) RPE spheres bound to the feeder layer. Middle: RPE cells from spheres are shown migrating onto the feeder layer (day 3). Right: higher power view of the boxed region from the middle panel. (D, left) RPE cells from spheres after migration onto the feeder layer (day 7). Middle: RPE cells from spheres that migrated from the feeder layer onto the surrounding culture dish (day 7). Right: RPE cells from spheres bound to feeder layer cells on Petri dishes after 1 month in culture. Date of download: 3/9/2018 The Association for Research in Vision and Ophthalmology Copyright © 2018. All rights reserved.